Synthesis and antimicrobial activities of two novel amino sugars derived from chloraloses

被引:13
|
作者
Yenil, Nilguen [1 ]
Ay, Emriye [1 ]
Ay, Kadir [1 ]
Oskay, Mustafa [2 ]
Maddaluno, Jacques [3 ,4 ,5 ]
机构
[1] Celal Bayar Univ, Sci & Arts Fac, Dept Chem, TR-45030 Muradiye, Manisa, Turkey
[2] Celal Bayar Univ, Sci & Arts Fac, Dept Biol, TR-45030 Manisa, Turkey
[3] Univ Rouen, IRCOF, CNRS, UMR 6014, F-76821 Mont St Aignan, France
[4] Univ Rouen, FR 3038, F-76821 Mont St Aignan, France
[5] INSA, F-76821 Mont St Aignan, France
关键词
Amino sugars; Antimicrobial activity; Chloraloses; Trichloroethylidene acetals; DERIVATIVES; PYRANOSES; AMIDES; RING;
D O I
10.1016/j.carres.2010.03.043
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-beta-L-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-alpha-D-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1617 / 1621
页数:5
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