Synthesis and antimicrobial activities of two novel amino sugars derived from chloraloses

被引：13

作者：

Yenil, Nilguen ^{[1
]}

Ay, Emriye ^{[1
]}

Ay, Kadir ^{[1
]}

Oskay, Mustafa ^{[2
]}

Maddaluno, Jacques ^{[3
,4
,5
]}

机构：

[1] Celal Bayar Univ, Sci & Arts Fac, Dept Chem, TR-45030 Muradiye, Manisa, Turkey

[2] Celal Bayar Univ, Sci & Arts Fac, Dept Biol, TR-45030 Manisa, Turkey

[3] Univ Rouen, IRCOF, CNRS, UMR 6014, F-76821 Mont St Aignan, France

[4] Univ Rouen, FR 3038, F-76821 Mont St Aignan, France

[5] INSA, F-76821 Mont St Aignan, France

来源：

CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 11期

关键词：

Amino sugars; Antimicrobial activity; Chloraloses; Trichloroethylidene acetals; DERIVATIVES; PYRANOSES; AMIDES; RING;

D O I：

10.1016/j.carres.2010.03.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-beta-L-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-alpha-D-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1617 / 1621

页数：5

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