Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases?

被引：121

作者：

Dulai, Parambir S. ^{[1
]}

Singh, Siddharth ^{[1
]}

Vande Casteele, Niels ^{[1
]}

Boland, Brigid S. ^{[1
]}

Rivera-Nieves, Jesus ^{[1
]}

Ernst, Peter B. ^{[1
]}

Eckmann, Lars ^{[1
]}

Barrett, Kim E. ^{[1
]}

Chang, John T. ^{[1
]}

Sandborn, William J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Gastroenterol, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2019年 / 17卷 / 13期

基金：

美国国家卫生研究院;

关键词：

Crohn's Disease; Classification; Ileal; Colonic; INFLAMMATORY-BOWEL-DISEASE; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; CEREVISIAE MANNAN ANTIBODIES; FECAL CALPROTECTIN LEVELS; EXTRAINTESTINAL MANIFESTATIONS; ULCERATIVE-COLITIS; SEROLOGICAL MARKERS; CAPSULE ENDOSCOPY; ESCHERICHIA-COLI; TERMINAL ILEUM;

D O I：

10.1016/j.cgh.2019.04.040

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease (CD) is an inflammatory bowel disease that can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. In the current review we evaluate the published literature regarding differences in epidemiology, natural history, pathogenesis, response to therapy, and disease monitoring, when stratified by disease location. Based on the available evidence consideration could be given to a new classification for CD, which splits it into ileum dominant (isolated ileal and ileocolonic) and isolated colonic disease. This may allow for a more optimized approach to clinical care and scientific research for CD.

引用

页码：2634 / 2643

页数：10

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