Gene Expression Profiling in Melasma in Korean Women

被引：25

作者：

Chung, Bo Young ^{[1
]}

Noh, Tai Kyung ^{[2
]}

Yang, Sang Hwa ^{[3
]}

Kim, Il Hwan ^{[4
]}

Lee, Mi Woo ^{[2
]}

Yoon, Tae Jin ^{[5
,6
]}

Chang, Sung Eun ^{[2
]}

机构：

[1] Hallym Univ, Kangnam Sacred Heart Hosp, Coll Med, Dept Dermatol, Seoul, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Dermatol, Seoul 138736, South Korea

[3] Yonsei Univ, Yonsei Biomolecule Res Initiat BK21, Seoul 120749, South Korea

[4] Korea Univ, Coll Med, Dept Dermatol, Seoul 136705, South Korea

[5] Gyeongsang Natl Univ, Inst Hlth Sci, Dept Dermatol, Jinju, South Korea

[6] Gyeongsang Natl Univ, Sch Med, Jinju, South Korea

来源：

DERMATOLOGY | 2014年 / 229卷 / 04期

关键词：

Melasma; Microarray analysis; Pathogenesis; MELANOCYTE-STIMULATING HORMONE; LESCH-NYHAN-DISEASE; ATOPIC-DERMATITIS; ULTRAVIOLET-RADIATION; SIGNALING PATHWAY; MOLECULAR-CLONING; ARACHIDONIC-ACID; BINDING-PROTEINS; LESIONAL SKIN; DT-DIAPHORASE;

D O I：

10.1159/000365080

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one. Objective: Our aim was to identify novel genes involved in the pathogenesis of melasma. Methods: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma. Results: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier. Conclusion: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women. (C) 2014 S. Karger AG, Basel

引用

页码：333 / 342

页数：10

共 62 条

[1] Cypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly [J].

Akum, BF ;

Chen, M ;

Gunderson, SI ;

Riefler, GM ;

Scerri-Hansen, MM ;

Firestein, BL .

NATURE NEUROSCIENCE, 2004, 7 (02) :145-152

[2] Reticulated pigmentary changes in a patient with a variant form of Lesch-Nyhan disease [J].

Alonso-Gonzalez, J. ;

Hernandez-Martin, A. ;

Garcia-Penas, J. J. ;

Colmenero, I. ;

Torrelo, A. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2012, 37 (05) :569-570

[3] Gene expression profiling analysis of solar lentigo in relation to immunohistochemical characteristics [J].

Aoki, H. ;

Moro, O. ;

Tagami, H. ;

Kishimoto, J. .

BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (06) :1214-1223

[4] Increased Expression of Nerve Growth Factor Receptor and Neural Endopeptidase in the Lesional Skin of Melasma [J].

Bak, Hana ;

Lee, Hyun Ju ;

Chang, Sung-Eun ;

Choi, Jee-Ho ;

Kim, Myeung Nam ;

Kim, Beom Joon .

DERMATOLOGIC SURGERY, 2009, 35 (08) :1244-1250

[5] Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiation [J].

Bellei, Barbara ;

Pitisci, Angela ;

Catricala, Caterina ;

Larue, Lionel ;

Picardo, Mauro .

PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (02) :309-325

[6] HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-κB activities [J].

Benedyk, Malgorzata ;

Sopalla, Claudia ;

Nacken, Wolfgang ;

Bode, Guenther ;

Melkonyan, Harut ;

Banfi, Botond ;

Kerkhoff, Claus .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (08) :2001-2011

[7] A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation [J].

Borgono, Carla A. ;

Michael, Iacovos P. ;

Komatsu, Nahoko ;

Jayakumar, Arumugam ;

Kapadia, Ravi ;

Clayman, Gary L. ;

Sotiropoulou, Georgia ;

Diamandis, Eleftherios P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (06) :3640-3652

[8] Impact of NAD(P)H:Quinone Oxidoreductase-1 on Pigmentation [J].

Choi, Tae-Young ;

Sohn, Kyung-Cheol ;

Kim, Jin-Hwa ;

Kim, Seong-Min ;

Kim, Cheol-Hee ;

Hwang, Jae-Sung ;

Lee, Jeung-Hoon ;

Kim, Chang Deok ;

Yoon, Tae-Jin .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (03) :784-792

[9] High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis [J].

de Jongh, GJ ;

Zeeuwen, PLJM ;

Kucharekova, M ;

Pfundt, R ;

van der Valk, PG ;

Blokx, W ;

Dogan, A ;

Hiemstra, PS ;

van de Kerkhof, PC ;

Schalkwijk, J .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (06) :1163-1173

[10] Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair [J].

de Koning, H. D. ;

van den Bogaard, E. H. ;

Bergboer, J. G. M. ;

Kamsteeg, M. ;

van Vlijmen-Willems, I. M. J. J. ;

Hitomi, K. ;

Henry, J. ;

Simon, M. ;

Takashita, N. ;

Ishida-Yamamoto, A. ;

Schalkwijk, J. ;

Zeeuwen, P. L. J. M. .

BRITISH JOURNAL OF DERMATOLOGY, 2012, 166 (06) :1245-1254

← 1 2 3 4 5 6 7 →