Discovery of respiratory syncytial virus (RSV) fusion inhibitor GS-5806 and clinical proof of concept in a human RSV challenge study

被引:0
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作者
Mackman, Richard L. [1 ]
Sangi, Michael [1 ]
Sperandio, David [1 ]
Parrish, Jay P. [1 ]
Eisenberg, Eugene [2 ]
Perron, Michel [3 ]
Hui, Hon [1 ]
Zhang, Lijun [1 ]
Siegel, Dustin [1 ]
Yang, Hai [1 ]
Saunders, Oliver [1 ]
Boojamra, Constantine [1 ]
Lee, Gary [3 ]
Samuel, Dharmaraj [3 ]
Babaoglu, Kerim [4 ]
Carey, Anne [5 ]
Gilbert, Brian E. [6 ]
Piedra, Pedro A. [6 ]
Strickley, Robert [7 ]
Alfredson, Thomas [7 ]
Iwata, Quynh [7 ]
Toteva, Maria [7 ]
Chan, Johann [7 ]
Wang, Wei K. [2 ]
Hayes, Jaclyn [2 ]
Stray, Kirsten [3 ]
Kincade, April [3 ]
Theodore, Dorothy [3 ]
Jordan, Robert [3 ]
Lewis, Sandy A. [8 ]
Li, Xiaoming [8 ]
O'Riordan, Thomas [8 ]
Kearney, Brian [8 ]
Ramanathan, Srini [8 ]
Jin, Feng [8 ]
Xin, Yan [8 ]
Desai, Manoj [1 ]
Chien, Jason W. [8 ]
Whitley, Richard J. [9 ]
DeVincenzo, John P. [10 ]
Cihlar, Tomas [3 ]
机构
[1] Gilead Sci Inc, Dept Med Chem, Foster City, CA 94404 USA
[2] Gilead Sci Inc, Dept Drug Metab, Foster City, CA 94404 USA
[3] Gilead Sci Inc, Dept Biol, Foster City, CA 94404 USA
[4] Gilead Sci Inc, Dept Struct Chem, Foster City, CA 94404 USA
[5] Gilead Sci Inc, Dept Drug Safety Evaluat, Foster City, CA 94404 USA
[6] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[7] Gilead Sci Inc, Dept Pharmaceut Dev & Mfg, Foster City, CA 94404 USA
[8] Gilead Sci Inc, Dept Clin Res, Foster City, CA 94404 USA
[9] Univ Alamaba, Sch Med, Birmingham, AL 35924 USA
[10] Univ Tennessee, Sch Med, Memphis, TN 38163 USA
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
352-MEDI
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页数:1
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