Innervation of the human minor salivary glands; immunohistochemical study for neurochemical substances

被引：5

作者：

Sato, Ayumi ^{[1
]}

Yajima, Takehiro ^{[1
]}

Tachiya, Daisuke ^{[1
]}

Ichikawa, Hiroyuki ^{[1
]}

Sato, Tadasu ^{[1
,2
]}

机构：

[1] Tohoku Univ, Grad Sch Dent, Div Oral & Craniofacial Anat, Sendai 9808575, Japan

[2] Tohoku Univ, Grad Sch Dent, Div Oral & Craniofacial Anat, 4-1 Seiryo Machi, Sendai 9808575, Japan

来源：

TISSUE & CELL | 2022年 / 79卷

关键词：

Minor salivary glands; TRPV2; Neurotransmitter agents; Human; Immunohistochemistry; SUPERIOR CERVICAL-GANGLION; HUMAN SUBMANDIBULAR-GLAND; CONTAINING NERVE-FIBERS; IMMUNOCYTOCHEMICAL LOCALIZATION; TYROSINE-HYDROXYLASE; PEPTIDE RECEPTORS; BLOOD-VESSELS; NEUROPEPTIDES; NEURONS; VIP;

D O I：

10.1016/j.tice.2022.101934

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Distributions of choline acetyltransferase (ChAT), vasoactive intestinal polypeptide (VIP), dopamine beta-hydrox-ylase (DBH), tyrosine hydroxylase (TH), neuropeptide Y (NPY) and the transient receptor potential cation channel subfamily V member 2 (TRPV2) were examined in the human minor salivary glands. ChAT-, VIP-and DBH-immunoreactive (-IR) nerve fibers were detected within nerve bundles and close to blood vessels and ducts in the salivary glands. Periacinar nerve fibers were commonly immunoreactive for ChAT in the Ebner's gland but infrequently in other salivary glands. Periacinar VIP-IR nerve fibers were numerous in the palatal gland, mod-erate in the lingual gland and relatively rare in the labial and Ebner's glands. Some TH-, NPY-and TRPV2-IR nerve fibers were also present around blood vessels and glandular acini in the palatal, lingual and Ebner's glands. Neuronal cells in the vicinity of Ebner's and lingual glands were immunoreactive for ChAT, VIP, TH and TRPV2. By confocal laser scanning microscopy, VIP-and ChAT-IR varicosities were located in the vicinity of myoepithelial and acinar cells in the minor salivary glands. The human minor salivary glands are probably innervated by parasympathetic and sympathetic nerves. Neurotransmitters including neuropeptides in these nerves are thought to be correlated to vasodilation and/or salivary secretion. Acetylcholine and VIP may regulate secretion of the saliva and its components in the salivary glands.

引用

页数：9

共 48 条

[1]

ALHADITHI BAK, 1988, J ANAT, V159, P83

[2] Sensory neurons in the human jugular ganglion [J].

Atsumi, Keiichiro ;

Yajima, Takehiro ;

Tachiya, Daisuke ;

Kokubun, Souichi ;

Shoji, Noriaki ;

Sasano, Takashi ;

Ichikawa, Hiroyuki ;

Sato, Tadasu .

TISSUE & CELL, 2020, 64

[3] NEUROPEPTIDES IN THE HUMAN SUPERIOR CERVICAL-GANGLION [J].

BAFFI, J ;

GORCS, T ;

SLOWIK, F ;

HORVATH, M ;

LEKKA, N ;

PASZTOR, E ;

PALKOVITS, M .

BRAIN RESEARCH, 1992, 570 (1-2) :272-278

[4] AUTONOMIC PATHWAYS IN THE ORBIT OF THE HUMAN-FETUS AND THE RHESUS-MONKEY [J].

BALJET, B ;

VANDERWERF, F ;

OTTO, AJ .

DOCUMENTA OPHTHALMOLOGICA, 1989, 72 (3-4) :247-264

[5] Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjogren's syndrome [J].

Batbayar, B ;

Nagy, G ;

Kövesi, G ;

Zelles, T ;

Fehér, E .

ARCHIVES OF ORAL BIOLOGY, 2004, 49 (07) :529-538

[6]

Batbayar Bayarchimeg, 2002, Orv Hetil, V143, P1585

[7] VASOACTIVE INTESTINAL PEPTIDE INTERACTS WITH ALPHA-ADRENERGIC-P-MEDIATED, CHOLINERGIC-P-MEDIATED, AND SUBSTANCE-P-MEDIATED RESPONSES IN RAT PAROTID AND SUBMANDIBULAR GLANDS [J].

BOBYOCK, E ;

CHERNICK, WS .

JOURNAL OF DENTAL RESEARCH, 1989, 68 (11) :1489-1494

[8] The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].

Caterina, MJ ;

Schumacher, MA ;

Tominaga, M ;

Rosen, TA ;

Levine, JD ;

Julius, D .

NATURE, 1997, 389 (6653) :816-824

[9] The expression of water channel proteins during human salivary gland development: a topographic study of aquaporins 1, 3 and 5 [J].

de Paula, Fernanda ;

Nakajima Teshima, Tathyane Harumi ;

Hsieh, Ricardo ;

Souza, Milena Monteiro ;

Coutinho-Camillo, Claudia Malheiros ;

Simonsen Nico, Marcello Menta ;

Lourenco, Silvia Vanessa .

JOURNAL OF MOLECULAR HISTOLOGY, 2017, 48 (5-6) :329-336

[10]

Demer JL, 1997, INVEST OPHTH VIS SCI, V38, P1774

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