Heart Failure, End-Systolic Pressure-Volume Relation

The problem of heart failure with normal or preserved ejection fraction (HFpEF) has been the subject of numerous studies. Mathematical relations between ejection fraction (EF) and the parameters describing linear and non-linear end-systolic pressure-volume relation (ESPVR) have been derived in previous publications. Consequently one can expect a link between observed percentage of heart failure and EF on the one hand, and indexes derived from the ESPVR on the other hand, which is the subject of this study. It is shown that important information can be derived from the ESPVR that can give better insight into the mechanics of ventricular contraction. Applications to clinical data published in the literature show the consistency of the mathematical formalism used.