Design, synthesis, and biological evaluations of (E)-2-(1-[2-mercapto-4-methyl-1-phenyl-1H-imidazol-5-yl]ethylidene)hydrazinecarbothioamide derivatives as antimicrobial agents

被引：1
|
作者：
Daraji, Drashti G. [1 ]
Rajani, Dhanji P. [2 ,3 ]
Jayanthi, Sivaraman [4 ]
Patel, Hitesh D. [1 ]
机构：
[1] Gujarat Univ, Sch Sci, Dept Chem, Navarangpura, Gujarat, India
[2] Microcare Lab, Surat, India
[3] TRC, Surat, India
[4] Vellore Inst Technol, Sch Bio Sci & Technol, Vellore, Tamil Nadu, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 59卷 / 01期
关键词：
MICROWAVE-ASSISTED SYNTHESIS; DIHYDROPTEROATE SYNTHASE; MOLECULAR DOCKING; CRYSTAL-STRUCTURES; ANTIBACTERIAL; DHPS; ANTIOXIDANT; INHIBITION; COMPLEX;
D O I：
10.1002/jhet.4378
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In recent year, the development of new drugs as antibacterial agents is an important resolution to overcome drug-resistant pathogens. Imidazole derivatives were synthesized using the microwave irradiation method and were characterized using spectral analysis techniques such as proton nuclear magnetic resonance, mass, and Fourier transform infrared spectroscopy. All the analogous were assessed for their in vitro antimicrobial activity and in silico; minimum inhibition concentration values of some conjugates were evaluated against extended spectrum beta-lactamases, vancomycin-resistant enterococci, and Methicillin-resistant Staphylococcus aureus strains from clinical samples. All the analogous were used as ligands in molecular docking and adsorption, distribution, metabolism, and excretion against saDHPS. Furthermore, compounds were also examined for their in vitro antituberculosis and antimalarial activity.
引用
收藏
页码：178 / 193
页数：16
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