Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates:: Correlation with outcome in solid organ transplant recipients with Cryptococcosis

被引：69

作者：

Kontoyiannis, Dimitrios P. ^{[1
]}

Lewis, Russell E. ^{[1
]}

Alexander, Barbara D. ^{[2
]}

Lortholary, Olivier ^{[3
,4
]}

Dromer, Francoise ^{[3
]}

Gupta, Krishan L. ^{[5
]}

John, George T. ^{[6
]}

del Busto, Ramon ^{[7
]}

Klintmalm, Goran B. ^{[8
]}

Somani, Jyoti ^{[9
]}

Lyon, G. Marshall ^{[9
]}

Pursell, Kenneth ^{[10
]}

Stosor, Valentina ^{[11
]}

Munoz, Patricia ^{[12
]}

Limaye, Ajit P. ^{[13
]}

Kalil, Andre C. ^{[14
]}

Pruett, Timothy L. ^{[15
]}

Garcia-Diaz, Julia ^{[16
]}

Humar, Atul ^{[17
]}

Houston, Sally ^{[18
]}

House, Andrew A. ^{[19
]}

Wray, Dannah ^{[20
]}

Orloff, Susan ^{[21
]}

Dowdy, Lorraine A. ^{[22
]}

Fisher, Robert A. ^{[23
]}

Heitman, Joseph ^{[3
,4
]}

Albert, Nathaniel D. ^{[1
]}

Wagener, Marilyn M. ^{[24
,25
]}

Singh, Nina ^{[24
,25
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Duke Univ, Med Ctr, Durham, NC USA

[3] Inst Pasteur, Paris, France

[4] Hop Necker Enfants Malad, Fac Med Paris Descartes, Paris, France

[5] Postgrad Inst Med Educ & Res, Chandigarh 160012, India

[6] Christian Med Coll & Hosp, Vellore 632004, Tamil Nadu, India

[7] Henry Ford Hosp, Detroit, MI 48202 USA

[8] Baylor Univ, Med Ctr, Dallas, TX USA

[9] Emory Univ, Atlanta, GA 30322 USA

[10] Univ Chicago, Chicago, IL 60637 USA

[11] Northwestern Univ, Chicago, IL 60611 USA

[12] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[13] Univ Washington, Seattle, WA 98195 USA

[14] Univ Nebraska, Omaha, NE 68182 USA

[15] Univ Virginia, Charlottesville, VA USA

[16] Alton Ochsner Med Fdn & Ochsner Clin, New Orleans, LA 70121 USA

[17] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON, Canada

[18] Univ S Florida, Tampa, FL USA

[19] Univ Western Ontario, London, ON, Canada

[20] Med Univ S Carolina, Charleston, SC 29425 USA

[21] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[22] Univ Miami, Miami, FL 33152 USA

[23] Virginia Commonwealth Univ, Richmond, VA USA

[24] VA Med Ctr, Pittsburgh, PA USA

[25] Univ Pittsburgh, Med Ctr, VA Pittsburgh Healthcare Syst, Infect Dis Sect 2A 137, Pittsburgh, PA 15240 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 02期

关键词：

D O I：

10.1128/AAC.00990-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

引用

页码：735 / 738

页数：4

共 23 条

[21] Cryptococcus neoformans in organ transplant recipients:: Impact of calcineurin-inhibitor agents on mortality [J].

Singh, Nina ;

Alexander, Barbara D. ;

Lortholary, Olivier ;

Dromer, Francoise ;

Gupta, Krishan L. ;

John, George T. ;

del Busto, Ramon ;

Klintmalm, Goran B. ;

Somani, Jyoti ;

Lyon, G. Marshall ;

Pursell, Kenneth ;

Stosor, Valentina ;

Munoz, Patricia ;

Limaye, Ajit P. ;

Kalil, Andre C. ;

Pruett, Timothy L. ;

Garcia-Diaz, Julia ;

Humar, Atul ;

Houston, Sally ;

House, Andrew A. ;

Wray, Dannah ;

Orloff, Susan ;

Dowdy, Lorraine A. ;

Fisher, Robert A. ;

Heitman, Joseph ;

Wagener, Marilyn M. ;

Husain, Shahid .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (05) :756-764

[22] In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients [J].

Steinbach, WJ ;

Singh, N ;

Miller, JL ;

Benjamin, DK ;

Schell, WA ;

Heitman, J ;

Perfect, JR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) :4922-4925

[23] Cryptococcosis in organ transplant recipients: An overview [J].

Vilchez, RA ;

Fung, J ;

Kusne, S .

AMERICAN JOURNAL OF TRANSPLANTATION, 2002, 2 (07) :575-580

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