Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

被引：12
|
作者：
Marselli, Lorella [1 ]
Bosi, Emanuele [1 ]
De Luca, Carmela [1 ]
Del Guerra, Silvia [1 ]
Tesi, Marta [1 ]
Suleiman, Mara [1 ]
Marchetti, Piero [1 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 22期
基金：
欧盟地平线“2020”;
关键词：
arginase; 2; polyamines; pancreatic islets; beta cells; type; diabetes; ORNITHINE-DECARBOXYLASE; L-ARGININE; METABOLISM; ISLETS; GENES; LOCALIZATION; DEFICIENCY; SPERMIDINE; TRANSPORT; PATHWAYS;
D O I：
10.3390/ijms222212099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
    Kahraman, Sevim
    Okawa, Erin R.
    Kulkarni, Rohit N.
    CURRENT DIABETES REPORTS, 2016, 16 (08)
  • [42] Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
    Sevim Kahraman
    Erin R. Okawa
    Rohit N. Kulkarni
    Current Diabetes Reports, 2016, 16
  • [43] Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?
    Ashcroft, Frances M.
    Rohm, Maria
    Clark, Anne
    Brereton, Melissa F.
    CELL METABOLISM, 2017, 26 (01) : 17 - 23
  • [44] Involvement of sulfatide in beta cells and type 1 and type 2 diabetes
    Buschard, K
    Blomqvist, M
    Osterbye, T
    Fredman, P
    DIABETOLOGIA, 2005, 48 (10) : 1957 - 1962
  • [45] Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes
    Coomans de Brachene, Alexandra
    Scoubeau, Corentin
    Musuaya, Anyishai E.
    Costa-Junior, Jose Maria
    Castela, Angela
    Carpentier, Julie
    Faoro, Vitalie
    Klass, Malgorzata
    Cnop, Miriam
    Eizirik, Decio L.
    DIABETOLOGIA, 2023, 66 (03) : 450 - 460
  • [46] Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes
    Gilon, Patrick
    Chae, Hee-Young
    Rutter, Guy A.
    Ravier, Magalie A.
    CELL CALCIUM, 2014, 56 (05) : 340 - 361
  • [47] Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes
    Quesada-Masachs, Estefania
    Zilberman, Samuel
    Rajendran, Sakthi
    Chu, Tiffany
    McArdle, Sara
    Kiosses, William B.
    Lee, Jae-Hyun M.
    Yesildag, Burcak
    Benkahla, Mehdi A.
    Pawlowska, Agnieszka
    Graef, Madeleine
    Pfeiffer, Susanne
    Mikulski, Zbigniew
    von Herrath, Matthias
    DIABETOLOGIA, 2022, 65 (02) : 387 - 401
  • [48] DNA methylation in the pathogenesis of type 2 diabetes in humans
    Davegardh, Cajsa
    Garcia-Calzon, Sonia
    Bacos, Karl
    Ling, Charlotte
    MOLECULAR METABOLISM, 2018, 14 : 12 - 25
  • [49] Role of mitochondria in pathogenesis of type 2 diabetes mellitus
    Pankaj Prasun
    Journal of Diabetes & Metabolic Disorders, 2020, 19 : 2017 - 2022
  • [50] The role of Toxoplasma gondii as a possible inflammatory agent in the pathogenesis of type 2 diabetes mellitus in humans
    Molan, Aus
    Nosaka, Kazunori
    Hunter, Michael
    Wang, Wei
    FAMILY MEDICINE AND COMMUNITY HEALTH, 2016, 4 (04): : 44 - 62
12345