Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

被引：12

作者：

Marselli, Lorella ^{[1
]}

Bosi, Emanuele ^{[1
]}

De Luca, Carmela ^{[1
]}

Del Guerra, Silvia ^{[1
]}

Tesi, Marta ^{[1
]}

Suleiman, Mara ^{[1
]}

Marchetti, Piero ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 22期

基金：

欧盟地平线“2020”;

关键词：

arginase; 2; polyamines; pancreatic islets; beta cells; type; diabetes; ORNITHINE-DECARBOXYLASE; L-ARGININE; METABOLISM; ISLETS; GENES; LOCALIZATION; DEFICIENCY; SPERMIDINE; TRANSPORT; PATHWAYS;

D O I：

10.3390/ijms222212099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.

引用

页数：11

共 50 条

[21] Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes
Marchetti, Piero
Bugliani, Marco
De Tata, Vincenzo
Suleiman, Mara
Marselli, Lorella
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2017, 5
[22] Mitochondrial Dysfunction in Pancreatic Alpha and Beta Cells Associated with Type 2 Diabetes Mellitus
Grubelnik, Vladimir
Zmazek, Jan
Markovic, Rene
Gosak, Marko
Marhl, Marko
LIFE-BASEL, 2020, 10 (12): : 1 - 16
[23] A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes
Marchetti, Piero
Suleiman, Mara
De Luca, Carmela
Baronti, Walter
Bosi, Emanuele
Tesi, Marta
Marselli, Lorella
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 103 : 83 - 93
[24] Bariatric surgery: beta cells in type 2 diabetes remission
Su, Yinjie
Zhao, Yanling
Zhang, Chaojun
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2016, 32 (02) : 122 - 131
[25] Pancreatic α Cells are Resistant toMetabolic Stress-induced Apoptosis in Type 2 Diabetes
Marroqui, Laura
Masini, Matilde
Merino, Beatriz
Grieco, Fabio A.
Millard, Isabelle
Dubois, Christine
Quesada, Ivan
Marchetti, Piero
Cnop, Miriam
Eizirik, Decio L.
EBIOMEDICINE, 2015, 2 (05): : 378 - 385
[26] Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction
Bugliani, Marco
Liechti, Robin
Cheon, Hwanju
Suleiman, Mara
Marselli, Lorella
Kirkpatrick, Clare
Filipponi, Franco
Boggi, Ugo
Xenarios, Ioannis
Syed, Farooq
Ladriere, Laurence
Wollheim, Claes
Lee, Myung-Shik
Marchetti, Piero
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2013, 367 (1-2) : 1 - 10
[27] IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes
Rajendran, Sakthi
Quesada-Masachs, Estefania
Zilberman, Samuel
Graef, Madeleine
Kiosses, William B.
Chu, Tiffany
Benkahla, Mehdi A.
Lee, Jae-Hyun Mason
von Herrath, Matthias
JOURNAL OF AUTOIMMUNITY, 2021, 123
[28] Role of pseudohypoxia in the pathogenesis of type 2 diabetes
Song, Jing
Yang, Xiaojuan
Yan, Liang-Jun
HYPOXIA, 2019, 7 : 33 - 40
[29] An overview of pancreatic beta-cell defects in human type 2 diabetes: Implications for treatment
Marchetti, Piero
Dotta, Francesco
Lauro, Davide
Purrello, Francesco
REGULATORY PEPTIDES, 2008, 146 (1-3) : 4 - 11
[30] LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes
Sanchez, Paulina Karen Mendoza
Khazaei, Mona
Gatineau, Eva
Geravandi, Shirin
Lupse, Blaz
Liu, Huan
Dringen, Ralf
Wojtusciszyn, Anne
Gilon, Patrick
Maedler, Kathrin
Ardestani, Amin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 568 : 158 - 166

← 1 2 3 4 5 →