Moving Closer to a Prognostic DNA Methylation Signature in Colon Cancer

被引：9

作者：

Carmona, F. Javier ^{[1
]}

Esteller, Manel ^{[1
,2
,3
]}

机构：

[1] Hosp Duran & Reynals, Canc Epigenet & Biol Program, Bellvitge Biomed Res Inst IDIBELL, Barcelona 08907, Catalonia, Spain

[2] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain

[3] ICREA, Barcelona, Catalonia, Spain

来源：

CLINICAL CANCER RESEARCH | 2011年 / 17卷 / 06期

关键词：

GENE O-6-METHYLGUANINE-DNA METHYLTRANSFERASE; PROMOTER HYPERMETHYLATION; COLORECTAL TUMORIGENESIS; INACTIVATION; TRANSITION; MUTATIONS;

D O I：

10.1158/1078-0432.CCR-10-3446

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although large panels of genes undergoing aberrant CpG island methylation in colorectal cancer have been identified, reliable predictors for clinical management in this tumor type remain elusive. A new DNA methylation signature affecting the extracellular matrix (ECM) pathway has been identified with potential prognostic value in colon cancer. Clin Cancer Res; 17(6); 1215-7. (C)2011 AACR.

引用

页码：1215 / 1217

页数：3

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