Electron Beam Intraoperative Radiotherapy (ELIOT) in Pregnant Women with Breast Cancer: From in Vivo Dosimetry to Clinical Practice

被引：10

作者：

Leonardi, Maria ^{[1
]}

Cecconi, Agnese ^{[2
,3
]}

Luraschi, Rosa ^{[4
]}

Rondi, Elena ^{[4
]}

Cattani, Federica ^{[4
]}

Lazzari, Roberta ^{[1
]}

Morra, Anna ^{[1
]}

Soto, Santos ^{[5
]}

Zanagnolo, Vanna ^{[6
]}

Galimberti, Viviana ^{[7
]}

Gentilini, Oreste ^{[7
,8
]}

Peccatori, Fedro ^{[9
]}

Jereczek-Fossa, Barbara ^{[1
,3
]}

Orecchia, Roberto ^{[2
,3
,10
]}

机构：

[1] European Inst Oncol, Adv Radiotherapy Ctr, Milan, Italy

[2] European Inst Oncol, Sci Direct, Milan, Italy

[3] Univ Milan, Milan, Italy

[4] European Inst Oncol, Unit Med Phys, Milan, Italy

[5] Med Sur Hosp, Breast Ctr, Mexico City, DF, Mexico

[6] European Inst Oncol, Gynecol Canc Surg, Milan, Italy

[7] European Inst Oncol, Breast Canc Surg, Milan, Italy

[8] San Raffaele Univ Hosp, Breast Surg Unit, Milan, Italy

[9] European Inst Oncol, Fertil & Procreat Unit, Milan, Italy

[10] CNAO Fdn, Natl Ctr Oncol Hadrontherapy, Pavia, Italy

来源：

BREAST CARE | 2017年 / 12卷 / 06期

关键词：

Breast cancer; Pregnancy; Radiation therapy; OF-THE-LITERATURE; RADIATION-EXPOSURE; MONTE-CARLO; IRRADIATION; PATIENT; OUTCOMES; ORGANS;

D O I：

10.1159/000479862

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. Patients and Methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breastconserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region. In December 2011, the first pregnant breast cancer patient underwent BCS and ELIOT (21 Gy at 90% isodose) during the 15th week of gestation. Results: The mean dose to the subdiaphragmatic external region in the 5 nonpregnant patients was 5.57 mGy, while pelvic measurements were below 1 mGy. The actual dosimetry of the pregnant patient showed a mean subdiaphragmatic dose of 4.34 mGy, a mean suprapubic dose of 1.64 mGy, and mean ovarian doses of 1.48 mGy (right-sided) and 1.44 mGy (left-sided). The expected dose to the fetus was estimated as 0.84 mGy (0.004% of the prescribed dose). Conclusion: ELIOT as an anticipated boost to the breast could be considered in pregnant women in the early second trimester, postponing whole-breast irradiation after delivery. (C) 2017 S. Karger GmbH, Freiburg

引用

页码：396 / 400

页数：5

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