Febrile Status Epilepticus: Current State of Clinical and Basic Research

被引：10
作者：
Ahmad, Saba [2 ]
Marsh, Eric D. [1 ,2 ]
机构：
[1] Childrens Hosp Philadelphia, Div Neurol, Dept Pediat, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
来源：
SEMINARS IN PEDIATRIC NEUROLOGY | 2010年 / 17卷 / 03期
关键词：
TEMPORAL-LOBE EPILEPSY; RESONANCE-IMAGING EVIDENCE; IMMATURE RAT MODEL; LONG-TERM; HIPPOCAMPAL EXCITABILITY; CONTROLLED-TRIAL; SEIZURES; SCLEROSIS; CHILDREN; CONVULSIONS;
D O I：
10.1016/j.spen.2010.06.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Febrile status epilepticus occurs in up to 5% of all cases of febrile seizures and has been linked to the development of focal epilepsy. This article reviews the clinical characteristics and treatment issues of febrile status. Controversy exists regarding the relationship of febrile status epilepticus to the subsequent development of epilepsy. This subject is discussed by first reviewing the clinical research literature and then highlighting the basic science research regarding this controversial question. The current literature appears to support a role for febrile status in the development of focal epilepsy but is clearly neither necessary nor sufficient in the focal epileptogenisis process. Multiple insults are likely necessary for a child with febrile status epilepticus to develop epilepsy later in life. Semin Pediatr Neurol 17:150-154 (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：150 / 154
页数：5
相关论文
共 56 条
  • [1] Convulsive and nonconvulsive status epilepticus in children
    Abend, Nicholas S.
    Marsh, Eric
    [J]. CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2009, 11 (04) : 262 - 272
  • [2] FACTORS PROGNOSTIC OF UNPROVOKED SEIZURES AFTER FEBRILE CONVULSIONS
    ANNEGERS, JF
    HAUSER, WA
    SHIRTS, SB
    KURLAND, LT
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (09) : 493 - 498
  • [3] Febrile seizures: An appropriate-aged model suitable for long-term studies
    Baram, TZ
    Gerth, A
    Schultz, L
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 1997, 98 (02): : 265 - 270
  • [4] Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures
    Bender, RA
    Dubé, C
    Gonzalez-Vega, R
    Mina, EW
    Baram, TZ
    [J]. HIPPOCAMPUS, 2003, 13 (03) : 399 - 412
  • [5] The natural history of mesial temporal lobe epilepsy
    Berg, Anne T.
    [J]. CURRENT OPINION IN NEUROLOGY, 2008, 21 (02) : 173 - 178
  • [6] Childhood-onset epilepsy with and without preceding febrile seizures
    Berg, AT
    Shinnar, S
    Levy, SR
    Testa, FM
    [J]. NEUROLOGY, 1999, 53 (08) : 1742 - 1748
  • [7] Complex febrile seizures
    Berg, AT
    Shinnar, S
    [J]. EPILEPSIA, 1996, 37 (02) : 126 - 133
  • [8] A PROSPECTIVE-STUDY OF RECURRENT FEBRILE SEIZURES
    BERG, AT
    SHINNAR, S
    HAUSER, WA
    ALEMANY, M
    SHAPIRO, ED
    SALOMON, ME
    CRAIN, EF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (16) : 1122 - 1127
  • [9] Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner
    Brewster, A
    Bender, RA
    Chen, YC
    Dube, C
    Eghbal-Ahmadi, M
    Baram, TZ
    [J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (11) : 4591 - 4599
  • [10] Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures
    Brewster, AL
    Bernard, JA
    Gall, CM
    Baram, TZ
    [J]. NEUROBIOLOGY OF DISEASE, 2005, 19 (1-2) : 200 - 207
123456