Biological roles and potential applications of immune cell-derived extracellular vesicles

被引：147
作者：
Wen, Chuan [1 ,2 ,3 ,4 ,5 ]
Seeger, Robert C. [1 ,2 ,3 ,4 ]
Fabbri, Muller [1 ,2 ,3 ,4 ]
Wang, Larry [6 ]
Wayne, Alan S. [1 ,2 ,3 ,4 ]
Jong, Ambrose Y. [1 ,2 ,3 ,4 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Dept Pediat, Childrens Ctr Canc & Blood Dis, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Div Hematol, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp 2, Div Oncol, Changsha, Hunan, Peoples R China
[4] Cent S Univ, Xiangya Hosp 2, Div Blood & Marrow Transplantat, Changsha, Hunan, Peoples R China
[5] Cent S Univ, Xiangya Hosp 2, Inst Pediat, Div Hematol,Childrens Med Ctr, Changsha, Hunan, Peoples R China
[6] Univ Southern Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Dept Pathol,Saban Res Inst,Childrens Hosp Los Ang, Los Angeles, CA 90033 USA
来源：
JOURNAL OF EXTRACELLULAR VESICLES | 2017年 / 6卷 / 01期
关键词：
Extracellular vesicles; exosomes; immune cells; natural-killer cells; cytotoxicity; theranostics; MATURE DENDRITIC CELLS; CD4(+) T-CELLS; ANTIGEN PRESENTATION; MOLECULAR-MECHANISMS; SECRETORY LYSOSOMES; MEDIATED APOPTOSIS; EXOSOME SECRETION; NKG2D LIGANDS; TUMOR-CELLS; P-SELECTIN;
D O I：
10.1080/20013078.2017.1400370
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extracellular vesicles (EVs) deliver bioactive macromolecules (i.e. proteins, lipids and nucleic acids) for intercellular communication in multicellular organisms. EVs are secreted by all cell types including immune cells. Immune cell-derived EVs modulate diverse aspects of the immune system to either enhance or suppress immune activities. The extensive effects of immune cell-derived EVs have become the focus of great interest for various nano-biomedical applications, ranging from the medical use of nanoplatform-based diagnostic agents to the development of therapeutic interventions as well as vaccine applications, and thus may be ideal for 'immune-theranostic'. Here, we review the latest advances concerning the biological roles of immune cell-derived EVs in innate and acquired immunity. The intercellular communication amongst immune cells through their EVs is highlighted, showing that all immune cell-derived EVs have their unique function(s) in immunity through intricate interaction(s). Natural-killer (NK) cell-derived EVs, for example, contain potent cytotoxic proteins and induce apoptosis to targeted cancer cells. On the other hand, cancer cell-derived EVs bearing NK ligands may evade immune surveillance and responses. Finally, we discuss possible medical uses for the immune cell-derived EVs as a tool for immune-theranostic: as diagnostic biomarkers, for use in therapeutic interventions and for vaccination.
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页数：19
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