Rising Trend in Waitlisting for Alcoholic Hepatitis With More Favorable Outcomes Than Other High Model for End-stage Liver Disease in the Current Era

被引:24
作者
Bittermann, Therese [1 ,2 ]
Mahmud, Nadim [1 ,2 ]
Weinberg, Ethan M. [1 ]
Reddy, K. Rajender [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Div Gastroenterol & Hepatol, 3400 Spruce St, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA USA
关键词
TRANSPLANTATION; SOCIETY;
D O I
10.1097/TP.0000000000004049
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. In the appropriate candidate, liver transplantation (LT) is a viable treatment for alcoholic hepatitis (AH). We compared the waitlisting trends and outcomes of AH patients in the context of others with high Model for End-stage Liver Disease (MELD) score. Methods. LT listings for AH between January 1, 2008, and June 12, 2020 were identified in the United Network for Organ Sharing database. Temporal trends in listings for AH were assessed. Covariate adjusted competing risks models evaluated waitlist mortality and LT rates between AH candidates and others with listing native MELD >= 30. Results. Between 2008 and 2019, waitlist additions for AH increased 6.5-fold. Waiting time for AH candidates was short (median 10 d). Delisting for clinical improvement was infrequent in AH, albeit higher than MELD >= 30 patients (3.3% versus 0.8%; P<0.001). Among 99 centers with >= 1 AH listing, AH patients accounted for 0.2%-18.2% of all alcohol-related listings and 0.6%-25.0% of those with native listing MELD >= 30. Overall listing volume was larger at these 99 centers than the 40 with no AH listings (P<0.001). AH candidates in 2014-2020 experienced improved waitlist survival (adjusted subhazard ratio, 0.67; 95% confidence interval, 0.52-0.86; P=0.002) and higher transplant rates (adjusted subhazard ratio, 1.14; 95% confidence interval, 1.04-1.25; P=0.006) versus other MELD >= 30 candidates. Conclusions. There has been a rising trend in waitlisting patients with AH and high MELD score. Liver disease causes influence waitlist outcomes and those of AH candidates are more favorable. Further research and allocation adjustments may be needed to ensure equitable organ allocation, based on liver disease cause, for those on the LT waitlist.
引用
收藏
页码:1401 / 1410
页数:10
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