HEPATITIS E VIRUS INFECTION AS A DIRECT CAUSE OF NEURALGIC AMYOTROPHY

被引：24

作者：

Silva, Mauro ^{[1
]}

Wicki, Benoit ^{[1
]}

Tsouni, Pinelopi ^{[1
]}

Cunningham, Sophie ^{[2
]}

Doerig, Christopher ^{[2
]}

Zanetti, Giorgio ^{[3
,4
]}

Aubert, Vincent ^{[5
]}

Sahli, Roland ^{[6
]}

Moradpour, Darius ^{[2
]}

Kuntzer, Thierry ^{[1
]}

机构：

[1] Univ Hosp Lausanne CHUV, Dept Clin Neurosci, Serv Neurol, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

[2] Univ Lausanne, Ctr Hosp Univ Vaudois, Serv Gastroenterol & Hepatol, Lausanne, Switzerland

[3] Univ Lausanne, Ctr Hosp Univ Vaudois, Infect Dis Serv, Lausanne, Switzerland

[4] Univ Lausanne, Ctr Hosp Univ Vaudois, Serv Hosp Prevent Med, Lausanne, Switzerland

[5] Univ Lausanne, Ctr Hosp Univ Vaudois, Serv Immunol & Allergy, Lausanne, Switzerland

[6] Univ Lausanne, Ctr Hosp Univ Vaudois, Inst Microbiol, Lausanne, Switzerland

来源：

MUSCLE & NERVE | 2016年 / 54卷 / 02期

关键词：

acute cervical radiculoplexopathy; anti-HEV antibody; HEV RNA; intravenous immunoglobulins; neuralgic amyotrophy; PATIENT;

D O I：

10.1002/mus.25096

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We describe a patient who developed neuralgic amyotrophy (NA) related to hepatitis E virus (HEV) infection. Methods: The patient underwent neurological and electrodiagnostic examinations, high-resolution analysis of serological changes, and HEV load profile, and was treated with intravenous immunoglobulin. Results: There was evidence of bilateral, asymmetric acute inflammatory cervical polyradiculopathy and possible brachial plexopathy. Positive serum anti-HEV IgM was followed by seroconversion to anti-HEV IgG positivity. A calculated anti-HEV antibody index was compatible with intrathecal synthesis, and HEV genotype 3 RNA was found in serum and cerebrospinal fluid (CSF). Liver function tests returned to normal within 6 weeks. Conclusions: Bilateral involvement of cervical nerve roots and/or plexus, elevated liver function tests, and abnormal CSF are typical features of HEV-associated NA. The pathogenesis involves possible immune-mediated mechanisms. However, our findings support the hypothesis that HEV-related NA is associated with direct infection.

引用

页码：325 / 327

页数：3

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