A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

被引：63

作者：

Gao, Xiaoxiang ^{[1
]}

Chen, Xiangjun ^{[2
]}

Hu, Hongjie ^{[1
]}

Wang, Xinyu ^{[1
]}

Yue, Wentong ^{[1
]}

Mu, Jing ^{[2
]}

Lou, Zhiyuan ^{[1
]}

Zhang, Ruiqi ^{[1
]}

Shi, Keren ^{[2
]}

Chen, Xue ^{[2
]}

Lin, Muyang ^{[1
]}

Qi, Baiyan ^{[2
]}

Zhou, Sai ^{[2
]}

Lu, Chengchangfeng ^{[3
]}

Gu, Yue ^{[2
]}

Yang, Xinyi ^{[2
]}

Ding, Hong ^{[1
]}

Zhu, Yangzhi ^{[1
]}

Huang, Hao ^{[1
]}

Ma, Yuxiang ^{[1
]}

Li, Mohan ^{[1
]}

Mishra, Aditya ^{[2
]}

Wang, Joseph ^{[1
,2
]}

Xu, Sheng ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Sch Med, Dept Radiol, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CODED EXCITATION; HEAT; TOMOGRAPHY; SYSTEM; TISSUE; MICROSCOPY; ILLNESS; AGENTS;

D O I：

10.1038/s41467-022-35455-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Electronic patches, based on various mechanisms, allow continuous and noninvasive monitoring of biomolecules on the skin surface. However, to date, such devices are unable to sense biomolecules in deep tissues, which have a stronger and faster correlation with the human physiological status than those on the skin surface. Here, we demonstrate a photoacoustic patch for three-dimensional (3D) mapping of hemoglobin in deep tissues. This photoacoustic patch integrates an array of ultrasonic transducers and vertical-cavity surface-emitting laser (VCSEL) diodes on a common soft substrate. The high-power VCSEL diodes can generate laser pulses that penetrate >2cm into biological tissues and activate hemoglobin molecules to generate acoustic waves, which can be collected by the transducers for 3D imaging of the hemoglobin with a high spatial resolution. Additionally, the photoacoustic signal amplitude and temperature have a linear relationship, which allows 3D mapping of core temperatures with high accuracy and fast response. With access to biomolecules in deep tissues, this technology adds unprecedented capabilities to wearable electronics and thus holds significant implications for various applications in both basic research and clinical practice.

引用

页数：13

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