Hepatic arterial floxuridine as second-line treatment for systemic fluorouracil-resistant colorectal liver metastases

被引：24
作者：
Fordy, C [1 ]
Glover, C [1 ]
Davies, MM [1 ]
Allen-Mersh, TG [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Sch Med, Dept Gastrointestinal Surg, London, England
来源：
BRITISH JOURNAL OF CANCER | 1998年 / 78卷 / 08期
关键词：
colorectal liver metastases; chemotherapy; fluorouracil resistance; hepatic arterial floxuridine;
D O I：
10.1038/bjc.1998.627
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatic arterial floxuridine (HAI) in 35 patients with systemic fluorouracil/folinic acid-resistant colorectal liver metastases achieved a 14% partial response and 26% disease stabilization rate, with a median response duration of 7 months from onset of HAI.
引用
收藏
页码：1058 / 1060
页数：3
相关论文
共 32 条
[1]   QUALITY-OF-LIFE AND SURVIVAL WITH CONTINUOUS HEPATIC-ARTERY FLOXURIDINE INFUSION FOR COLORECTAL LIVER METASTASES [J].
ALLENMERSH, TG ;
EARLAM, S ;
FORDY, C ;
ABRAMS, K ;
HOUGHTON, J .
LANCET, 1994, 344 (8932) :1255-1260
[2]   SIGNIFICANCE OF A FALL IN SERUM CEA CONCENTRATION IN PATIENTS TREATED WITH CYTO-TOXIC CHEMOTHERAPY FOR DISSEMINATED COLORECTAL-CANCER [J].
ALLENMERSH, TG ;
KEMENY, N ;
NIEDZWIECKI, D ;
SHURGOT, B ;
DALY, JM .
GUT, 1987, 28 (12) :1625-1629
[3]   THE SICKNESS IMPACT PROFILE - DEVELOPMENT AND FINAL REVISION OF A HEALTH-STATUS MEASURE [J].
BERGNER, M ;
BOBBITT, RA ;
CARTER, WB ;
GILSON, BS .
MEDICAL CARE, 1981, 19 (08) :787-805
[4]   EFFECT OF ABERRANT HEPATIC ARTERIAL ANATOMY ON TUMOR RESPONSE TO HEPATIC-ARTERY INFUSION OF FLOXURIDINE FOR COLORECTAL LIVER METASTASES [J].
BURKE, D ;
EARLAM, S ;
FORDY, C ;
ALLENMERSH, TG .
BRITISH JOURNAL OF SURGERY, 1995, 82 (08) :1098-1100
[5]   Hepatic arterial cannulation for regional chemotherapy is safe in patients with a liver metastasis volume of less than 1 litre [J].
Burke, D ;
Fordy, C ;
Earlam, SA ;
AllenMersh, TG .
BRITISH JOURNAL OF CANCER, 1997, 75 (08) :1213-1216
[6]   RANDOMIZED COMPARISON OF 2 SCHEDULES OF FLUOROURACIL AND LEUCOVORIN IN THE TREATMENT OF ADVANCED COLORECTAL-CANCER [J].
BUROKER, TR ;
OCONNELL, MJ ;
WIEAND, HS ;
KROOK, JE ;
GERSTNER, JB ;
MAILLIARD, JA ;
SCHAEFER, PL ;
LEVITT, R ;
KARDINAL, CG ;
GESME, DH .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (01) :14-20
[7]   MEASURING PSYCHOLOGICAL AND PHYSICAL DISTRESS IN CANCER-PATIENTS - STRUCTURE AND APPLICATION OF THE ROTTERDAM-SYMPTOM-CHECKLIST [J].
DEHAES, JCJM ;
VANKNIPPENBERG, FCE ;
NEIJT, JP .
BRITISH JOURNAL OF CANCER, 1990, 62 (06) :1034-1038
[8]   MEASUREMENT OF RESPONSE TO TREATMENT IN COLORECTAL LIVER METASTASES [J].
DWORKIN, MJ ;
BURKE, D ;
EARLAM, S ;
FORDY, C ;
ALLENMERSH, TG .
BRITISH JOURNAL OF CANCER, 1995, 71 (04) :873-876
[9]   Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases [J].
Earlam, S ;
Glover, C ;
Fordy, C ;
Burke, D ;
AllenMersh, TG .
JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (01) :171-175
[10]   Effect of regional and systemic fluorinated pyrimidine chemotherapy on quality of life in colorectal liver metastasis patients [J].
Earlam, S ;
Glover, C ;
Davies, M ;
Fordy, C ;
AllenMersh, TG .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (05) :2022-2029
1234