High rate of IgE-mediated histamine release from rat mesenteric mast cells

被引:2
|
作者
Inagaki, N [1 ]
Kawasaki, H [1 ]
Nagai, H [1 ]
机构
[1] Gifu Pharmaceut Univ, Dept Pharmacol, Gifu 5028585, Japan
关键词
histamine release; mast cell; rat mesenterium;
D O I
10.1538/expanim.50.187
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
IgE-dependent histamine release from rat mesenteric mast cells was investigated. Excised mesenterium was cut into pieces and incubated with IgE overnight at 4 degreesC for sensitization. Over 10 pieces of mesenterium specimen could be prepared from a rat. Antigen-induced histamine release from mesenterium specimen was initiated rapidly and reached a plateau in 5 min. In an optimal condition, over 50% of total histamine was released. In contrast, unpurified and purified peritoneal mast cells released only 22.5% and 5.3% of total histamine, respectively, upon IgE stimulation. Tranilast, a mast cell stabilizer, inhibited the histamine release from mesenteric mast cells significantly. The mesenterium might be a useful material for studying tissue-associated mast cell activation.
引用
收藏
页码:187 / 190
页数:4
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