Ganglioside GM1 mimics: Lipophilic substituents improve affinity for cholera toxin

被引：17

作者：

Arosio, D ^{[1
]}

Baretti, S ^{[1
]}

Cattaldo, S ^{[1
]}

Potenza, D ^{[1
]}

Bernardi, A ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 21期

关键词：

D O I：

10.1016/j.bmcl.2003.07.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ganglioside GM1 mimics including (R)-2-hydroxy-3-cyclohexylpropionic acid or (R)-2-hydroxy-3-phenylpropionic acid as replacements for NeuAc are stronger cholera toxin binders than the parent ligand 2, which includes (R)-2-hydroxy-propionic acid. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3831 / 3834

页数：4

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