The p53 family: guardians of maternal reproduction

被引：210

作者：

Levine, Arnold J. ^{[2
,3
]}

Tomasini, Richard ^{[5
,6
]}

McKeon, Frank D. ^{[7
]}

Mak, Tak W. ^{[8
]}

Melino, Gerry ^{[1
,4
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med, Biochem IDI IRCCS Lab, I-00133 Rome, Italy

[2] Inst Adv Studies, Princeton, NJ 08540 USA

[3] Univ Med & Dent New Jersey, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[4] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

[5] Inst Natl Sante, F-13288 Marseille 9, France

[6] Rech Med Unite 624, F-13288 Marseille 9, France

[7] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[8] Princess Margaret Hosp, Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2C1, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 04期

基金：

英国医学研究理事会;

关键词：

PROTECTS MOUSE OOCYTES; DNA-DAMAGE; P63; P73; MICE; GENE; SUPPRESSOR; OVULATION; ANTIGEN; CELLS;

D O I：

10.1038/nrm3086

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.

引用

页码：259 / +

页数：7

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