Lipid status, paraoxonase-1 activity and metabolic parameters in serum of heifers and lactating cows related to oxidative stress

被引：17

作者：

Antoncic-Svetina, M. ^{[2
]}

Turk, R. ^{[1
]}

Svetina, A. ^{[1
]}

Geres, D. ^{[3
,4
]}

Rekic, B. ^{[5
]}

Juretic, D. ^{[6
]}

机构：

[1] Univ Zagreb, Dept Pathophysiol, Fac Vet Med, HR-10000 Zagreb, Croatia

[2] Inst Cardiovasc Prevent & Rehabil Zagreb, Zagreb, Croatia

[3] Univ Zagreb, Fac Vet Med, Dept Reprod, HR-10000 Zagreb, Croatia

[4] Univ Zagreb, Fac Vet Med, Clin Obstet, HR-10000 Zagreb, Croatia

[5] Hlth Care Ctr Centar, Med Biochem Lab, Zagreb, Croatia

[6] Univ Zagreb, Dept Med Biochem & Hematol, Fac Pharm & Biochem, HR-10000 Zagreb, Croatia

来源：

RESEARCH IN VETERINARY SCIENCE | 2011年 / 90卷 / 02期

关键词：

Serum lipids; HDL; Paraoxonase-1; Oxidative stress; Heifers; Lactating cows; LOW-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; DAIRY-COWS; PLASMA-LIPOPROTEINS; ATHEROSCLEROSIS; ANTIOXIDANTS; BOVINE; HDL;

D O I：

10.1016/j.rvsc.2010.05.022

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The objective of this study was to investigate serum lipids, metabolic parameters and activity of the anti-oxidative enzyme paraoxonase-1 (PON1). The study was conducted on non-pregnant heifers with optimal health status and on healthy dairy cows in the period of intensive lactation, assuming that the energy and metabolic demands during lactation reduce anti-oxidative protection. Total cholesterol and HDL-cholesterol concentrations were significantly higher (P < 0.05) in lactating cows than in heifers. Bilirubin concentration and gamma-glutamyltransferase (GGT) activity were also significantly higher in lactating cows (P < 0.05), indicating increased hepatic efforts of cows to meet energy requirements for lactation. Significantly lower PON1 activity and PON1/HDL ratio in lactating cows compared to heifers (P < 0.05) showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress. Concurrent increase in total and HDL-cholesterol during lactation indicated that the HDL particle is a major carrier of cholesterol in cows. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：298 / 300

页数：3

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