The glycosylation in SARS-CoV-2 and its receptor ACE2

被引：148

作者：

Gong, Yanqiu ^{[1
,2
,3
]}

Qin, Suideng ^{[4
]}

Dai, Lunzhi ^{[1
,2
,3
]}

Tian, Zhixin ^{[4
]}

机构：

[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Gen Practice, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[3] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China

[4] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, Shanghai 200092, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2021年 / 6卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

TANDEM MASS-SPECTROMETRY; ELECTRON-TRANSFER DISSOCIATION; DATA-INDEPENDENT ACQUISITION; N-LINKED GLYCOPEPTIDES; LECTIN AFFINITY-CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; GLYCOPROTEIN GLYCAN STRUCTURES; CARBON-LIQUID-CHROMATOGRAPHY; CURATED RELATIONAL DATABASE; SITE-SPECIFIC GLYCOSYLATION;

D O I：

10.1038/s41392-021-00809-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 235 million individuals and led to more than 4.8 million deaths worldwide as of October 5 2021. Cryo-electron microscopy and topology show that the SARS-CoV-2 genome encodes lots of highly glycosylated proteins, such as spike (S), envelope (E), membrane (M), and ORF3a proteins, which are responsible for host recognition, penetration, binding, recycling and pathogenesis. Here we reviewed the detections, substrates, biological functions of the glycosylation in SARS-CoV-2 proteins as well as the human receptor ACE2, and also summarized the approved and undergoing SARS-CoV-2 therapeutics associated with glycosylation. This review may not only broad the understanding of viral glycobiology, but also provide key clues for the development of new preventive and therapeutic methodologies against SARS-CoV-2 and its variants.

引用

页数：24

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