Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)

被引：23
|
作者：
Zhu, Ning [1 ]
Liu, Yihuan [1 ]
Feng, Weiyang [1 ]
Huang, Weijun [1 ]
Zhang, Zilong [1 ]
Hu, Xin [1 ,2 ]
Fang, Zheng [1 ]
Li, Zhenjiang [1 ,3 ]
Guo, Kai [1 ,3 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211800, Jiangsu, Peoples R China
[2] Nanjing Tech Univ, Coll Mat Sci & Engn, Nanjing 211800, Jiangsu, Peoples R China
[3] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211800, Jiangsu, Peoples R China
来源：
EUROPEAN POLYMER JOURNAL | 2016年 / 80卷
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Sn(OTf)(2); Chemoselective ring-opening polymerization; Thiol-terminated poly(epsilon-caprolactone); RING-OPENING POLYMERIZATION; CONTROLLED RADICAL POLYMERIZATION; POLY EPSILON-CAPROLACTONE; TRIMETHYLENE CARBONATE; DELTA-VALEROLACTONE; L-LACTIDE; COPOLYMERS; CHEMISTRY; CATALYSTS; REACTOR;
D O I：
10.1016/j.eurpolymj.2016.04.010
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel continuous flow protecting-group-free synthetic approach was developed to thiol-terminated poly(epsilon-caprolactone). Sn(OTf)(2) catalyzed unprotected 6-mercapto-l-hexanol initiating chemoselective ring-opening polymerization of epsilon-caprolactone was conducted in PTFE tubular reactor. This continuous flow polymerization platform achieved quantitative chemoselectivity and fast polymerization that cannot be done in batch. By changing the [monomer]/[initiator] feed ratio, the molecular weights of products were well controlled with narrow molecular weight distributions. The structure of the resultant thiol-terminated poly(epsilon-caprolactone) was demonstrated by NMR, MALDI TOF MS and SEC. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：234 / 239
页数：6
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