Hepatitis B virus and hepatitis C virus infection among HIV-1-infected injection drug users in Dali, China: prevalence and infection status in a cross-sectional study

被引:15
作者
Dong, Yuan [1 ,2 ]
Qiu, Chao [1 ,2 ]
Xia, Xueshan [3 ]
Wang, Jing [1 ,2 ]
Zhang, Haiyan [4 ]
Zhang, Xiaoyan [1 ,2 ]
Xu, Jianqing [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Key Lab Med Mol Virol, Minist Educ Hlth,Shanghai Med Coll, Shanghai 201508, Peoples R China
[3] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
[4] Dali Municipal Ctr Dis Control & Prevent, Yunnan, Peoples R China
关键词
HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL THERAPY; GENOTYPE DISTRIBUTION; CORE PROTEIN; CHRONIC CARRIERS; HIV COHORT; COINFECTION; HCV; SUPERINFECTION; CLEARANCE;
D O I
10.1007/s00705-014-2311-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
To assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and to investigate their mutual influences on infection status among human immunodeficiency virus type 1 (HIV-1)seropositive injection drug users (IDUs). A cross-sectional study was conducted among HIV infected IDUs in Dali, China. The participants were tested for serological markers of HBV and HCV infection, alanine transaminase (ALT) activity and CD4(+) T cell count. HCV genotype was determined by sequencing. Of 529 patients, 498 (94.1 %) HIV infected IDUs agreed to participate. The overall prevalence of HCV infection (anti-HCV antibody positive) and spontaneous HCV clearance were 90.8 % (452/498) and 21.5 % (97/452), respectively. Of 411 subjects who had not received HBV vaccine, 296 (72.0 %) were positive for antibody against HBV core antigen (HBcAb), while 274 (66.7 %) were positive for both HCV antibody and HBcAb. HBV antigens were detected in 52 of the HBV-infected subjects (17.6 %). HCV clearance was associated with HBV antigenemia (p = 0.0002) and higher CD4(+) T cell count (p = 0.0294). Resolved HBV infection was associated with HCV genotype 3 (p = 0.0365). HBV and HCV infection are highly prevalent and mutually influence infection status in HIV-1 infected IDUs in Dali, China.
引用
收藏
页码:929 / 936
页数:8
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