Incretin-Based Therapies for Diabetic Complications: Basic Mechanisms and Clinical Evidence

被引：39

作者：

Kawanami, Daiji ^{[1
]}

Matoba, Keiichiro ^{[1
]}

Sango, Kazunori ^{[2
]}

Utsunomiya, Kazunori ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Dept Internal Med, Div Diabet Metab & Endocrinol,Minato Ku, 3-25-8 Nishi Shinbashi, Tokyo 1058461, Japan

[2] Tokyo Metropolitan Inst Med Sci, Diabet Neuropathy Project, Dept Sensory & Motor Syst, Setagaya Ku, 2-1-6 Kamikitazawa, Tokyo 1568506, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 08期

基金：

日本学术振兴会;

关键词：

incretin; DPP-4; glucose-dependent insulinotropic polypeptide (GIP); GLP-1; diabetes; diabetic complications; cardiovascular disease; GLUCAGON-LIKE PEPTIDE-1; BLOOD-RETINAL BARRIER; DEPENDENT INSULINOTROPIC POLYPEPTIDE; DIPEPTIDYL PEPTIDASE-4 INHIBITION; ANALOG LIRAGLUTIDE PROTECTS; OXIDATIVE STRESS; RECEPTOR AGONIST; GLP-1; ANALOG; IV INHIBITOR; CARDIOVASCULAR OUTCOMES;

D O I：

10.3390/ijms17081223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An increase in the rates of morbidity and mortality associated with diabetic complications is a global concern. Glycemic control is important to prevent the development and progression of diabetic complications. Various classes of anti-diabetic agents are currently available, and their pleiotropic effects on diabetic complications have been investigated. Incretin-based therapies such as dipeptidyl peptidase (DPP)-4 inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RA) are now widely used in the treatment of patients with type 2 diabetes. A series of experimental studies showed that incretin-based therapies have beneficial effects on diabetic complications, independent of their glucose-lowering abilities, which are mediated by anti-inflammatory and anti-oxidative stress properties. Based on these findings, clinical studies to assess the effects of DPP-4 inhibitors and GLP-1RA on diabetic microvascular and macrovascular complications have been performed. Several but not all studies have provided evidence to support the beneficial effects of incretin-based therapies on diabetic complications in patients with type 2 diabetes. We herein discuss the experimental and clinical evidence of incretin-based therapy for diabetic complications.

引用

页数：17

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