A novel sensor made of Antimony Doped Tin Oxide-silica composite sol on a glassy carbon electrode modified by single-walled carbon nanotubes for detection of norepinephrine

被引:29
作者
Wang, Zhao [1 ]
Wang, Kai [1 ]
Zhao, Lu [1 ]
Chai, Shigan [1 ]
Zhang, Jinzhi [1 ]
Zhang, Xiuhua [1 ]
Zou, Qichao [1 ]
机构
[1] Hubei Univ, Hubei Collaborat Innovat Ctr Advanced Organ Chem, Coll Chem & Chem Engn, Minist Educ,Key Lab Synth & Applicat Organ Funct, Wuhan 430062, Hubei, Peoples R China
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 80卷
基金
中国国家自然科学基金;
关键词
MIP; ATO; Silica sol; Composite sol; Norepinephrine; SWNTs; PERFORMANCE LIQUID-CHROMATOGRAPHY; SNO2; THIN-FILMS; ELECTROCHEMICAL SENSOR; OPTICAL-PROPERTIES; PASTE ELECTRODE; DOPAMINE; ATO; GEL; NORADRENALINE; NANOPARTICLES;
D O I
10.1016/j.msec.2017.03.227
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
In this study, we designed a novel molecularly imprinted polymer (MIP), Antimony Doped Tin Oxide (ATO)-silica composite sol, which was made using a sol-gel method. Then a sensitive and selective imprinted electrochemical sensor was constructed with the ATO-silica composite sol on a glassy carbon electrode modified by single-walled carbon nanotubes (SWNTs). The introduction of SWNTs increased the sensitivity of the MIP sensor. The surface morphology of the MIP and MIP/SWNTs were characterized by scanning electron microscopy (SEM), and the optimal conditions for detection were determined. The oxidative peak current increased linearly with the concentration of norepinephrine in the range of 9.99 x 10(-8) M to 1.50 x 10(-5) M, as detected by cyclic voltammetry (CV), the detection limit was 3.33 x 10(-8) M (S/N = 3). In addition, the proposed electrochemical sensors were successfully applied to detect the norepinephrine concentration in human blood serum samples. Tile recoveries of the sensors varied from 99.67% to 104.17%, indicating that the sensor has potential for the determination of norepinephrine in clinical tests. Moreover, the imprinted electrochemical sensor was used to selectively detect norepinephrine. The analytical application was conducted successfully and yielded accurate and precise results. (C) 2017 Published by Elsevier B.V.
引用
收藏
页码:180 / 186
页数:7
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