Five-FU@CuS/NH2-UiO-66 as a drug delivery system for 5-fluorouracil to colorectal cancer cells

被引：2
作者：
Gholami, Marjan [1 ]
Darroudi, Majid [2 ,3 ]
Hekmat, Azadeh [1 ]
Khazaei, Majid [4 ]
机构：
[1] Islamic Azad Univ, Sci & Res Branch, Dept Biol, Tehran, Iran
[2] Mashhad Univ Med Sci, Nucl Med Res Ctr, Mashhad 9177948564, Razavi Khorasan, Iran
[3] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol & Nanotechnol, Mashhad, Razavi Khorasan, Iran
[4] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran
来源：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2022年 / 36卷 / 09期
关键词：
5-FU; CT-26 mouse colorectal cancer cell line; CuS-NPs; drug delivery; metal-organic framework (MOFs); COPPER SULFIDE; NANOPARTICLES; CUS; METAL; COMPOSITES; AGENT;
D O I：
10.1002/jbt.23145
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, copper sulfide nanoparticles (CuS-NPs), which can improve the antiproliferative properties of conventional anticancer drugs such as 5-fluorouracil (5-FU), were incorporated into the pores of amine-functionalized UiO-66 (CuS/NH2-UiO-66). The introduced nano-drug delivery system was exerted to perform an in vitro treatment on CT-26 mouse colorectal cancer cells. The synthesized final product was labeled as 5-FU@CuS/NH2-UiO-66 and characterized through conventional methods including X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) analysis, Ultraviolet-Visible (UV-Vis) analysis, Inductively coupled plasma mass spectrometry (ICP-MS), and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In contrast to 5-FU, the outcomes of the cytotoxicity assay lacked any comparable results for 5-FU@CuS/NH2-UiO-66.
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页数：10
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