Synthesis and Enantiomeric Resolution of Medetomidine

被引：6

作者：

Fakhraian, H. ^{[1
]}

Toulabi, H. ^{[1
]}

Choobdari, E. ^{[2
]}

Peyrovi, M. H. ^{[2
]}

Ghanbary, H. Hadj ^{[1
]}

机构：

[1] Imam Hossein Univ, Dept Chem, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

来源：

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL | 2015年 / 47卷 / 02期

关键词：

ADRENERGIC ACTIVITIES; ANALOGS; DEXMEDETOMIDINE; LIGANDS; DESIGN; OXIDE;

D O I：

10.1080/00304948.2015.1005985

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Medetomidine {4-[l-(2,3-dimethylphenyl)ethyl]-3H-imidazole], 5} is a selective α2-adrenoceptor agonist used in veterinary medicine for its analgesic and sedative properties. It is also an alternative and environmentally acceptable anti-fouling biocide which impedes the settlement of barnacles at nanomolar concentrations and replaces toxic antifouling coatings based on heavy metals. Several syntheses of medetomidine have been reported. The first method for the preparation of 5 and of other related 4-benzylimidazoles was described in a patent starting from 2,3-dimethylbromobenzene as shown in Scheme 1; unfortunately the yields were not reported. Copyright © Taylor & Francis Group, LLC.

引用

页码：141 / 148

页数：8

共 26 条

[1] SYNTHESIS AND ALPHA-ADRENERGIC ACTIVITIES OF 2-SUBSTITUTED AND 4-SUBSTITUTED IMIDAZOLINE AND IMIDAZOLE ANALOGS [J].