DIPNECH: when to suggest this diagnosis on CT

被引：40

作者：

Chassagnon, G. ^{[1
]}

Favelle, O. ^{[1
]}

Marchand-Adam, S. ^{[2
]}

De Muret, A. ^{[3
]}

Revel, M. P. ^{[4
]}

机构：

[1] CHU Tours, Hop Bretonneau, Dept Radiol, F-37000 Tours, France

[2] Hop Bretonneau, Dept Pulm Med, F-37000 Tours, France

[3] CHU Tours, Hop Trousseau, Dept Pathol, F-37170 Chambray Les Tours, France

[4] Paris Descartes Univ, Grp Hosp Cochin Hotel Dieu, AP HP, Radiol Dept,Sorbonne Paris Cite, F-75014 Paris, France

来源：

CLINICAL RADIOLOGY | 2015年 / 70卷 / 03期

关键词：

NEUROENDOCRINE CELL HYPERPLASIA; IDIOPATHIC DIFFUSE HYPERPLASIA; HIGH-RESOLUTION CT; SPECTRUM; MANIFESTATIONS; PROLIFERATIONS; TUMORS;

D O I：

10.1016/j.crad.2014.10.012

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an under-recognized disease characterized by proliferation of neuroendocrine cells in the bronchial wall. It is considered a pre-invasive lesion for lung carcinoid tumours and is found in 5.4% of patients undergoing surgical resection for lung carcinoid tumours. Other manifestations of DIPNECH include bronchial obstruction and formation of tumorlets. DIPNECH preferentially affects middle-aged women. Patients are either asymptomatic or present with long-standing dyspnoea due to obstructive syndrome that can be mistaken for asthma. At CT, mosaic attenuation with multiple small nodules is very suggestive of DIPNECH. The aim of this review is to describe DIPNECH-related CT features and correlate them with histology, in order to help radiologists suggest this diagnosis and distinguish DIPNECH from other causes of mosaic perfusion. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：317 / 325

页数：9

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