Formal Total Synthesis of Okadaic Acid via Regiocontrolled Gold(I)-Catalyzed Spiroketalizations

被引：58

作者：

Fang, Chao ^{[1
]}

Pang, Yucheng ^{[1
]}

Forsyth, Craig J. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 20期

关键词：

STEREOCHEMICAL ASSIGNMENT; PROTEIN PHOSPHATASES; NATURAL-PRODUCTS; (-)-USHIKULIDE; POLYETHER; KETONES; ALKYNES; DOMAIN; TOXIN;

D O I：

10.1021/ol101833h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both C19 and C34 spiroketal domains of okadaic acid were assembled using gold(I) chloride catalyzed spiroketalizations, and the two resulting fragments were coupled to give the C15-C38 fragment of okadaic acid, a known intermediate for the total synthesis of this important natural product.

引用

页码：4528 / 4531

页数：4

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