Cancer-testis antigen expression in triple-negative breast cancer

被引：80

作者：

Curigliano, G. ^{[1
]}

Viale, G. ^{[2
,3
]}

Ghioni, M. ^{[2
,3
]}

Jungbluth, A. A. ^{[4
]}

Bagnardi, V. ^{[5
,6
]}

Spagnoli, G. C. ^{[8
]}

Neville, A. M. ^{[7
]}

Nole, F. ^{[1
]}

Rotmensz, N. ^{[5
]}

Goldhirsch, A. ^{[1
]}

机构：

[1] Ist Europeo Oncol, Dept Med, Div Med Oncol, I-20141 Milan, Italy

[2] Ist Europeo Oncol, Div Pathol, I-20141 Milan, Italy

[3] Univ Milan, Sch Med, Milan, Italy

[4] Mem Sloan Kettering Canc Ctr, Ludwig Inst Canc Res, New York Branch, New York, NY 10021 USA

[5] Ist Europeo Oncol, Div Epidemiol & Biostatist, I-20141 Milan, Italy

[6] Univ Milano Bicocca, Dept Stat, Milan, Italy

[7] Ludwig Inst Canc Res, New York, NY USA

[8] Univ Basel Hosp, Inst Surg Res & Hosp Management, Basel, Switzerland

来源：

ANNALS OF ONCOLOGY | 2011年 / 22卷 / 01期

关键词：

breast cancer; cancer-testis antigens; MAGE; NY-ESO; 1; T-CELL RESPONSES; NY-ESO-1; PROTEIN; GENE-EXPRESSION; CANCER/TESTIS ANTIGENS; PREDICTIVE-VALUE; VACCINATION; ANTIBODY; TUMORS; KI-67; IMMUNOTHERAPY;

D O I：

10.1093/annonc/mdq325

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Cancer-testis (CT) antigens, frequently expressed in human germline cells but not in somatic tissues, may become aberrantly reexpressed in different cancer types. The aim of this study was to investigate the expression of CT antigens in breast cancer. Patients and methods: A total of 100 selected invasive breast cancers, including 50 estrogen receptor (ER) positive/HER2 negative and 50 triple negative (TN), were examined for NY-ESO-1 and MAGE-A expression by immunohistochemistry. Results: A significantly higher expression of MAGE-A and NY-ESO-1 was detected in TN breast cancers compared with ER-positive tumors (P = 0.04). MAGE-A expression was detected in 13 (26%) TN cancers compared with 5 (10%) ER-positive tumors (P = 0.07). NY-ESO-1 expression was confirmed in nine (18%) TN tumor samples compared with two (4%) ER-positive tumors. Conclusions: MAGE-A and NY-ESO-1 CT antigens are expressed in a substantial proportion of TN breast cancers. Because of the limited therapeutic options for this group of patients, CT antigen-based vaccines might prove to be useful for patients with this phenotype of breast cancer.

引用

页码：98 / 103

页数：6

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