Rapid Simultaneous Determination of Eight Benzimidazoles in Animal Feed by LC-MS-MS

被引：10

作者：

Li, Cun ^{[2
]}

Wu, Yin-Liang ^{[1
]}

Yang, Ting ^{[1
]}

Zhang, Yan ^{[1
]}

机构：

[1] Ningbo Agr Prod Qual Detector Ctr, Ningbo 315040, Zhejiang, Peoples R China

[2] Hebei Univ Engn, Coll Agr, Handan 056038, Peoples R China

来源：

CHROMATOGRAPHIA | 2011年 / 73卷 / 1-2期

关键词：

Column liquid chromatography-electrospray tandem mass spectrometry; Animal feedstuffs; Benzimidazoles; SOLID-PHASE EXTRACTION; LIQUID-CHROMATOGRAPHY; THIABENDAZOLE; RESIDUES; HPLC; ANTHELMINTICS; FLUBENDAZOLE; METABOLITES; HPTLC;

D O I：

10.1007/s10337-010-1838-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A rapid, sensitive and reliable LC-MS-MS method for the determination of eight benzimidazoles in animal feed was developed and validated. Samples were extracted with acidic acetonitrile. The extract was diluted with 0.1% formic acid in water, and analyzed by LC-MS-MS on a Waters XBridge (TM) C-18 column with acetonitrile/0.1% formic acid in water as mobile phase. The samples were quantified with the matrix standard calibration curve method. Good linearity was obtained for eight benzimidazoles at a concentration of 0.005-2.5 mu g mL(-1) with a linear relative coefficient more than 0.990. Recoveries of 84.0-104.0% with CVs of 2.50-7.50% were obtained. Limit of detection was 2.1-63.0 mu g kg(-1). The method demonstrated to be suitable for the determination of eight benzimidazoles in animal feed samples.

引用

页码：59 / 65

页数：7

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