Interaction between EEG and Drug Concentration to Predict Response to Noxious Stimulation during Sedation-Analgesia: Effect of the A118G Genetic Polymorphism

被引：0

作者：

Melia, Umberto ^{[1
]}

Vallverdu, Montserrat ^{[1
]}

Jospin, Mathieu ^{[2
]}

Fernando Valencia, Jose ^{[3
]}

Jensen, Erik W. ^{[1
]}

Gambus, Pedro L. ^{[4
]}

Perera Lluna, Alexandre ^{[1
]}

Caminal, Pere ^{[1
]}

机构：

[1] CIBER BBN, Dept ESAII, Biomed Engn Res Ctr, Barcelonatech, Barcelona, Spain

[2] Quantium Med SL, Mataro, Spain

[3] Univ San Buenaventura, Dept Elect Engn, Cali, Colombia

[4] Univ Barcelona, Dept Anesthesiol, Hosp Clin, Barcelona, Spain

来源：

2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2014年

关键词：

AUDITORY-EVOKED POTENTIALS; OPIOID RECEPTOR GENE; PROPOFOL; DEPTH; REMIFENTANIL; AGE;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The level of sedation in patients undergoing medical procedures is affected by the interaction between the effect of the anesthetic and analgesic agents and the pain stimuli. The presence of the A118G single nucleotide polymorphism (SNP) in the OPRM1 gene affects the requirements of opioids for patients undergoing sedation-analgesia. The purpose of this work is to evaluate the influence of the SNP A118G in OPRM1 on EEG measures for the prediction of the response to pain stimulation during endoscopy procedure. The proposed measures were based on power spectral density and auto-mutual information function. It was found that the statistical performances of the EEG measures improved when the presence of the SNP was taken into account (prediction probability Pk>0.9).

引用

页码：4298 / 4301

页数：4

共 2 条

[1] Prediction of Response to Noxious Stimulation during Sedation-Analgesia by Refined Multiscale Entropy Analysis of EEG
Valencia, Jose F.
Melia, Umberto S. P.
Vallverdu, Montserrat
Jospin, Mathieu
Jensen, Erik W.
Porta, Alberto
Gambus, Pedro
Caminal, Pere
2014 8TH CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS (ESGCO), 2014, : 63 - +
[2] Modeling the Influence of the A118G Polymorphism in the OPRM1 Gene and of Noxious Stimulation on the Synergistic Relation between Propofol and Remifentanil Sedation and Analgesia in Endoscopic Procedures
Borrat, Xavier
Troconiz, Inaki F.
Valencia, Jose F.
Rivadulla, Silvia
Sendino, Oriol
Llach, Josep
Munoz, Jenifer
Castellvi-Bel, Sergi
Jospin, Mathieu
Jensen, Erik W.
Castells, Antoni
Gambus, Pedro L.
ANESTHESIOLOGY, 2013, 118 (06) : 1395 - 1407

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