Synthesis of [2H4]oxymetazoline and [14C]oxymetazoline

An efficient synthesis of [H-2(4)] and [C-14]oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [H-2(4)]oxymetazoline from [H-2(4)]ethylene diamine was achieved in one step with a 40% yield. The synthesis of [C-14]oxymetazoline from potassium [C-14]cyanide was achieved in two steps with an overall radiochemical yield of 67%.