Biomolecular recognition based on single gold nanoparticle light scattering

被引：640

作者：

Raschke, G

Kowarik, S

Franzl, T

Sonnichsen, C

Klar, TA

Feldmann, J

Nichtl, A

Kürzinger, K

机构：

[1] Univ Munich, Dept Phys, Photon & Optoelect Grp, D-80799 Munich, Germany

[2] Univ Munich, CeNS, D-80799 Munich, Germany

[3] Roche Diagnost GmbH, D-82372 Penzberg, Germany

来源：

NANO LETTERS | 2003年 / 3卷 / 07期

关键词：

D O I：

10.1021/nl034223+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for biomolecular recognition is reported using light scattering of a single gold nanoparticle functionalized with biotin. Addition of streptavidin and subsequent specific binding events alter the dielectric environment of the nanoparticle, resulting in a spectral shift of the particle plasmon resonance. As we use single nanoparticles showing a homogeneous scattering spectrum, spectral shifts as small as 2 meV can be detected.

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收藏

页码：935 / 938

页数：4

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