Palladium-Catalyzed Direct Arylation of Free NH2-Substituted Thiophene Derivatives

被引：67
|
作者：
Derridj, Fazia
Roger, Julien [1 ]
Djebbar, Safia
Doucet, Henri [1 ]
机构：
[1] Univ Rennes Catalyse & Organometall, Inst Sci Chim Rennes, CNRS UMR 6226, F-35042 Rennes, France
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 19期
关键词：
C-H ARYLATION; COUPLING REACTIONS; ARYL HALIDES; FUNCTIONALIZATION; HETEROAROMATICS; CYCLIZATION; CLEAVAGE;
D O I：
10.1021/ol101758w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed direct 2- or 5-arylation of some free NH2-substituted thiophene derivatives was found to proceed in high yields using a variety of aryl bromides. In the course of these reactions, no coupling of the aryl bromide with the thiophene NH2 substituent was detected. The presence of an ester substituent on C2 of thiophene was found to be useful to block this highly reactive carbon.
引用
收藏
页码：4320 / 4323
页数：4
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