Reduction of mutant huntingtin in oligodendroglia rescues myelination and behavioural deficits in a model of Huntington disease

被引:0
|
作者
Bardile, C. F. [1 ]
Garcia-Miralles, M. [1 ]
Caron, N. [1 ]
Teo, R. [1 ]
Hayden, M. R. [1 ,2 ,3 ]
Pouladi, M. A. [1 ,3 ]
机构
[1] Translat Lab Genet Med, Immunos, Singapore, Singapore
[2] Univ British Columbia, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC, Canada
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
WTH07-14
引用
收藏
页码:218 / 218
页数:1
相关论文
共 50 条
  • [41] Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
    Valentina Fodale
    Roberta Pintauro
    Manuel Daldin
    Roberta Altobelli
    Maria Carolina Spiezia
    Monica Bisbocci
    Douglas Macdonald
    Alberto Bresciani
    Scientific Reports, 10
  • [42] Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease
    Rodrigues, Filipe B.
    Byrne, Lauren M.
    Johnson, Eileanoir
    Wijeratne, Peter
    de Vita, Enrico
    Alexander, Daniel
    Palermo, Giuseppe
    Czech, Christian
    Schobel, Scott
    Scahill, Rachael
    Heslegrave, Amanda
    Zetterberg, Henrik
    Wild, Edward
    NEUROLOGY, 2019, 92 (15)
  • [43] Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs
    Tong, Huichun
    Yang, Tianqi
    Liu, Li
    Li, Caijuan
    Sun, Yize
    Jia, Qingqing
    Qin, Yiyang
    Chen, Laiqiang
    Zhao, Xianxian
    Zhou, Gongke
    Yan, Sen
    Li, Xiao-Jiang
    Li, Shihua
    NEUROBIOLOGY OF DISEASE, 2023, 187
  • [44] Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice
    Liang Jing
    Siying Cheng
    Yongcheng Pan
    Qiong Liu
    Weili Yang
    Shihua Li
    Xiao-Jiang Li
    Molecular Neurobiology, 2021, 58 : 5112 - 5126
  • [45] Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin - A potential mechanism for loss of huntingtin function in Huntington's disease
    Busch, A
    Engemann, S
    Lurz, R
    Okazawa, H
    Lehrach, H
    Wanker, EE
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) : 41452 - 41461
  • [46] Soluble mutant huntingtin drives early human pathogenesis in Huntington's disease
    Miguez, Andres
    Gomis, Cinta
    Vila, Cristina
    Monguio-Tortajada, Marta
    Fernandez-Garcia, Sara
    Bombau, Georgina
    Galofre, Mireia
    Garcia-Bravo, Maria
    Sanders, Phil
    Fernandez-Medina, Helena
    Poquet, Blanca
    Salado-Manzano, Cristina
    Roura, Santiago
    Alberch, Jordi
    Segovia, Jose Carlos
    Allen, Nicholas D.
    Borras, Francesc E.
    Canals, Josep M.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2023, 80 (08)
  • [47] Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
    Andrés Miguez
    Cinta Gomis
    Cristina Vila
    Marta Monguió-Tortajada
    Sara Fernández-García
    Georgina Bombau
    Mireia Galofré
    María García-Bravo
    Phil Sanders
    Helena Fernández-Medina
    Blanca Poquet
    Cristina Salado-Manzano
    Santiago Roura
    Jordi Alberch
    José Carlos Segovia
    Nicholas D. Allen
    Francesc E. Borràs
    Josep M. Canals
    Cellular and Molecular Life Sciences, 2023, 80
  • [48] Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease
    Caron, Nicholas S.
    Banos, Raul
    Yanick, Christopher
    Aly, Amirah E.
    Byrne, Lauren M.
    Smith, Ethan D.
    Xie, Yuanyun
    Smith, Stephen E. P.
    Potluri, Nalini
    Black, Hailey Findlay
    Casal, Lorenzo
    Ko, Seunghyun
    Cheung, Daphne
    Kim, Hyeongju
    Seong, Ihn Sik
    Wild, Edward J.
    Song, Ji-Joon
    Hayden, Michael R.
    Southwell, Amber L.
    JOURNAL OF NEUROSCIENCE, 2021, 41 (04): : 780 - 796
  • [49] Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice
    Jing, Liang
    Cheng, Siying
    Pan, Yongcheng
    Liu, Qiong
    Yang, Weili
    Li, Shihua
    Li, Xiao-Jiang
    MOLECULAR NEUROBIOLOGY, 2021, 58 (10) : 5112 - 5126
  • [50] Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease
    Byrne, Lauren M.
    Rodrigues, Filipe B.
    Johnson, Eileanor B.
    Wijeratne, Peter A.
    De Vita, Enrico
    Alexander, Daniel C.
    Palermo, Giuseppe
    Czech, Christian
    Schobel, Scott
    Scahill, Rachael I.
    Heslegrave, Amanda
    Zetterberg, Henrik
    Wild, Edward J.
    SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (458)