Repair of spinal cord injury by transplantation of olfactory ensheathing cells

被引：38

作者：

Raisman, Geoffrey ^{[1
]}

机构：

[1] UCL, Inst Neurol, Spinal Repair Unit, London WC1N 3BG, England

来源：

COMPTES RENDUS BIOLOGIES | 2007年 / 330卷 / 6-7期

关键词：

adult; CNS; axotomy; regeneration; paraplegia; stem cells;

D O I：

10.1016/j.crvi.2007.03.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Repair of spinal cord injury requires that severed axons are able to regenerate. Regrowth of axons is impeded by the loss of astrocytic pathways caused at the time of injury. Ensheathing glial cells cultured from the adult olfactory system can be transplanted into lesions and mediate both regeneration of axons and recovery of function.

引用

页码：557 / 560

页数：4

共 16 条

[1]

CAJAL SR, 1928, DEGENERATION REGNERA

[2] Olfactory horizontal basal cells demonstrate a conserved multipotent progenitor phenotype [J].

Carter, LA ;

MacDonald, JL ;

Roskams, AJ .

JOURNAL OF NEUROSCIENCE, 2004, 24 (25) :5670-5683

[3]

Huard JMT, 1998, J COMP NEUROL, V400, P469

[4]

Keyvan-Fouladi N, 2003, J NEUROSCI, V23, P9428

[5] Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells [J].

Li, Y ;

Field, PM ;

Raisman, G .

SCIENCE, 1997, 277 (5334) :2000-2002

[6] Interaction of transplanted olfactory-ensheathing cells and host astrocytic processes provides a bridge for axons to regenerate across the dorsal root entry zone [J].

Li, Y ;

Carlstedt, T ;

Berthold, CH ;

Raisman, G .

EXPERIMENTAL NEUROLOGY, 2004, 188 (02) :300-308

[7]

Li Y, 2003, J NEUROSCI, V23, P727

[8]

Li Y, 1998, J NEUROSCI, V18, P10514

[9]

LI Y, IN PRESS NEUROSURGER

[10] Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord [J].

Lu, J ;

Féron, F ;

Mackay-Sim, A ;

Waite, PME .

BRAIN, 2002, 125 :14-21

← 1 2 →