Genetic diversity of HLA-A2: Evolutionary and functional significance

被引：86

作者：

Browning, M ^{[1
]}

Krausa, P ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,MOLEC IMMUNOL GRP,OXFORD OX3 9DU,ENGLAND

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 04期

关键词：

D O I：

10.1016/0167-5699(96)80614-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA-A2 is the most common HLA class I specificity and is found at high frequency is most populations. Recent studies have shown that this specificity is encoded by at least 17 different alleles, whose distribution varies markedly between different populations. Here, Michael Browning and Peter Krausa explore the evolutionary and functional significance of the genetic diversity within HLA-A2.

引用

页码：165 / 170

页数：6

共 43 条

[21]

IMANISHI I, 1992, P 11 INT HIST WORKSH, P1065

[22] GENETIC-POLYMORPHISM WITHIN HLA-A-ASTERISK-02 - SIGNIFICANT ALLELIC VARIATION REVEALED IN DIFFERENT POPULATIONS [J].

KRAUSA, P ;

BRYWKA, M ;

SAVAGE, D ;

HUI, KM ;

BUNCE, M ;

NGAI, JLF ;

TEO, DLT ;

ONG, YW ;

BAROUCH, D ;

ALLSOP, CEM ;

HILL, AVS ;

MCMICHAEL, AJ ;

BODMER, JG ;

BROWNING, MJ .

TISSUE ANTIGENS, 1995, 45 (04) :223-231

[23] POSITIONING OF A PEPTIDE IN THE CLEFT OF HLA-A2 BY COMPLEMENTING AMINO-ACID CHANGES [J].

LATRON, F ;

MOOTS, R ;

ROTHBARD, JB ;

GARRETT, TPJ ;

STROMINGER, JL ;

MCMICHAEL, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11325-11329

[24] GORILLA CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX ALLELES - COMPARISON TO HUMAN AND CHIMPANZEE CLASS-I [J].

LAWLOR, DA ;

WARREN, E ;

TAYLOR, P ;

PARHAM, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06) :1491-1509

[25]

LOMBARDI G, 1991, TRANSPLANT P, V23, P446

[26] ROLES OF THE 6 PEPTIDE-BINDING POCKETS OF THE HLA-A2 MOLECULE IN ALLORECOGNITION BY HUMAN CYTOTOXIC T-CELL CLONES [J].

MATSUI, M ;

HIOE, CE ;

FRELINGER, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :674-678

[27]

MATSUI M, 1995, J IMMUNOL, V154, P1088

[28] EMERGING PRINCIPLES FOR THE RECOGNITION OF PEPTIDE ANTIGENS BY MHC CLASS-I MOLECULES [J].

MATSUMURA, M ;

FREMONT, DH ;

PETERSON, PA ;

WILSON, IA .

SCIENCE, 1992, 257 (5072) :927-934

[29]

MCADAM SN, 1995, J IMMUNOL, V154, P6421

[30] EFFECT OF MUTATIONS AND VARIATIONS OF HLA-A2 ON RECOGNITION OF A VIRUS PEPTIDE EPITOPE BY CYTO-TOXIC LYMPHOCYTES-T [J].

MCMICHAEL, AJ ;

GOTCH, FM ;

SANTOSAGUADO, J ;

STROMINGER, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9194-9198

← 1 2 3 4 5 →