Genetic diversity of HLA-A2: Evolutionary and functional significance

被引：86

作者：

Browning, M ^{[1
]}

Krausa, P ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,MOLEC IMMUNOL GRP,OXFORD OX3 9DU,ENGLAND

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 04期

关键词：

D O I：

10.1016/0167-5699(96)80614-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA-A2 is the most common HLA class I specificity and is found at high frequency is most populations. Recent studies have shown that this specificity is encoded by at least 17 different alleles, whose distribution varies markedly between different populations. Here, Michael Browning and Peter Krausa explore the evolutionary and functional significance of the genetic diversity within HLA-A2.

引用

页码：165 / 170

页数：6

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