Advances in pituitary pathology - Pituitary tumor gene expression profiles

被引：0
作者：
Lloyd, RV [1 ]
Jin, L [1 ]
Kobayashi, I [1 ]
机构：
[1] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
来源：
ENDOCRINOLOGIST | 2003年 / 13卷 / 04期
关键词：
DNA array; pituitary; adenomas; RNA expression;
D O I：
10.1097/01.TEN.0000084156.76564.46
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Use of DNA microarrays to explore gene expression on a global level is being applied to the study of pituitary tumors to learn more about pathogenesis, medical treatment, and prognosis of these tumors. Early studies have identified several new genes in human pituitary tumors, which are unique to growth hormone, corticotropin, and nonfunctional tumors. These new genes provide insight into the pathogenesis of specific tumor types and might serve as targets for chemotherapy and for targeting of tumors that are uniquely overexpressing specific gene products.
引用
收藏
页码：347 / 350
页数：4
相关论文
共 36 条
  • [1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    Alizadeh, AA
    Eisen, MB
    Davis, RE
    Ma, C
    Lossos, IS
    Rosenwald, A
    Boldrick, JG
    Sabet, H
    Tran, T
    Yu, X
    Powell, JI
    Yang, LM
    Marti, GE
    Moore, T
    Hudson, J
    Lu, LS
    Lewis, DB
    Tibshirani, R
    Sherlock, G
    Chan, WC
    Greiner, TC
    Weisenburger, DD
    Armitage, JO
    Warnke, R
    Levy, R
    Wilson, W
    Grever, MR
    Byrd, JC
    Botstein, D
    Brown, PO
    Staudt, LM
    [J]. NATURE, 2000, 403 (6769) : 503 - 511
  • [2] Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
    Alon, U
    Barkai, N
    Notterman, DA
    Gish, K
    Ybarra, S
    Mack, D
    Levine, AJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) : 6745 - 6750
  • [3] The cytogenesis and pathogenesis of pituitary adenomas
    Asa, SL
    Ezzat, S
    [J]. ENDOCRINE REVIEWS, 1998, 19 (06) : 798 - 827
  • [4] Molecular classification of cutaneous malignant melanoma by gene expression profiling
    Bittner, M
    Meitzer, P
    Chen, Y
    Jiang, Y
    Seftor, E
    Hendrix, M
    Radmacher, M
    Simon, R
    Yakhini, Z
    Ben-Dor, A
    Sampas, N
    Dougherty, E
    Wang, E
    Marincola, F
    Gooden, C
    Lueders, J
    Glatfelter, A
    Pollock, P
    Carpten, J
    Gillanders, E
    Leja, D
    Dietrich, K
    Beaudry, C
    Berens, M
    Alberts, D
    Sondak, V
    Hayward, N
    Trent, J
    [J]. NATURE, 2000, 406 (6795) : 536 - 540
  • [5] Emmert-Buck MR, 2000, MOL CARCINOGEN, V27, P158, DOI 10.1002/(SICI)1098-2744(200003)27:3<158::AID-MC2>3.0.CO
  • [6] 2-2
  • [7] Laser capture microdissection
    EmmertBuck, MR
    Bonner, RF
    Smith, PD
    Chuaqui, RF
    Zhuang, ZP
    Goldstein, SR
    Weiss, RA
    Liotta, LA
    [J]. SCIENCE, 1996, 274 (5289) : 998 - 1001
  • [8] ERNESTUS RI, 1992, ACTA HISTOCHEM, P159
  • [9] Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction
    Evans, CO
    Young, AN
    Brown, MR
    Brat, DJ
    Parks, JS
    Neish, AS
    Oyesiku, NM
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (07) : 3097 - 3107
  • [10] Molecular pathogenesis of pituitary tumors
    Farrell, WE
    Clayton, RN
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 2000, 21 (03) : 174 - 198
1234