NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis

被引：58
|
作者：
Fuentes, Eduardo [1 ,2 ]
Gibbins, Jonathan M. [3 ]
Holbrook, Lisa M. [3 ]
Palomo, Ivan [1 ]
机构：
[1] Univ Talca, Platelet Res Ctr, Dept Clin Biochem & Immunohaematol, Fac Hlth Sci,Interdisciplinary Excellence Res Pro, Talca, Chile
[2] Univ Talca, Nucl Cient Multidisciplinario, Talca, Chile
[3] Univ Reading, Sch Biol Sci, Inst Cardiovasc & Metab Res, Reading, Berks, England
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2018年 / 28卷 / 07期
关键词：
Platelet; Antiplatelet; Oxidative stress; NADPH oxidase; NOX2; UP-REGULATION; HYDROGEN-PEROXIDE; SUPEROXIDE ANION; BLOOD-PLATELETS; RECEPTOR; RELEASE; GENERATION; KINASE; INFLAMMATION; DYSFUNCTION;
D O I：
10.1016/j.tcm.2018.03.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Oxidative stress represents an imbalance between the production of reactive oxygen species (ROS) and the cellular antioxidant system. Increased levels of oxidative stress contribute to the development of atherosclerosis that eventually leads to thrombosis; a principle cause of heart attacks and strokes. Thrombosis is a consequence of platelet activation and aggregate formation within the circulation. Platelet ROS are mostly generated by reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis. The present article aims to highlight the relative contribution of NOX2 as a key target of different platelet activation pathways and antiplatelet treatment. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：429 / 434
页数：6
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