Copper-catalyzed, oxidative sp2 C-H cyanation: facile synthesis of aromatic carbonitriles

被引：8
|
作者：
Liu, Jin-Qiang [1 ]
Hao, Bao-Yu [2 ,3 ]
Zou, Hao [2 ]
Zhang, Wei-Han [2 ]
Chen, Xin-Zhi [3 ]
机构：
[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Luoyang 471022, Peoples R China
[2] Hutchison MediPharma Ltd, Shanghai 201203, Peoples R China
[3] Zhejiang Univ, Dept Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China
来源：
ARKIVOC | 2014年
基金：
高等学校博士学科点专项科研基金;
关键词：
C-H activation; cyanation; copper catalyzed; aryl carbonitriles; NITRILES; CYANIDE; N; N-DIMETHYLFORMAMIDE; HETEROARENES; ALCOHOLS; INDOLES;
D O I：
10.3998/ark.5550190.p008.682
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cu(OAc)(2)-catalyzed regioselective oxidative C-H cyanation of two different types of aromatics was described, providing facile access to functionalized heterocycles in good yields. Control experiments suggest the copper chelation-assisted oxidative C-H activation mechanism.
引用
收藏
页码：72 / 93
页数：22
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