Reproducible pharmacogenomic profiling of cancer cell line panels

被引：205

作者：

Haverty, Peter M. ^{[1
]}

Lin, Eva ^{[2
]}

Tan, Jenille ^{[2
]}

Yu, Yihong ^{[2
]}

Lam, Billy ^{[2
]}

Lianoglou, Steve ^{[1
]}

Neve, Richard M. ^{[2
]}

Artin, Scott M. ^{[2
]}

Ettleman, Jeff S. ^{[2
]}

Yauch, Robert L. ^{[2
]}

Bourgon, Richard ^{[1
]}

机构：

[1] Genentech Inc, Dept Bioinformat & Computat Biol, 1 DNA Way, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Discovery Oncol, 1 DNA Way, San Francisco, CA 94080 USA

来源：

NATURE | 2016年 / 533卷 / 7603期

关键词：

BREAST-CANCER; IDENTIFICATION; SENSITIVITY; ANNOTATION; VARIANTS; QUALITY; GENES;

D O I：

10.1038/nature17987

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The use of large-scale genomic and drug response screening of cancer cell lines depends crucially on the reproducibility of results. Here we consider two previously published screens, plus a later critique of these studies. Using independent data, we show that consistency is achievable, and provide a systematic description of the best laboratory and analysis practices for future studies.

引用

页码：333 / +

页数：18

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