Diastereoselective Synthesis of 6-Trifluoromethyl-5,6-dihydropyrans via Phosphine-Catalyzed [4+2] Annulation of α-Benzylallenoates with Ketones

被引：130
|
作者：
Wang, Tong [1 ]
Ye, Song [1 ]
机构：
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 18期
基金：
中国国家自然科学基金;
关键词：
ELECTRON-DEFICIENT OLEFINS; ENANTIOSELECTIVE 3+2 ANNULATIONS; DIELS-ALDER REACTIONS; CYCLOADDITION REACTIONS; ASYMMETRIC-SYNTHESIS; CHIRAL PHOSPHINES; CARBON-CARBON; ALLENOATES; ALDEHYDES; ESTERS;
D O I：
10.1021/ol101762z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The highly diastereoselective synthesis of 6-trifluoromethyl-5,6-dihydropyrans was realized by the phosphine-catalyzed [4 + 2] annulation of ethyl alpha-benzylallenoates and trifluoromethyl ketones.
引用
收藏
页码：4168 / 4171
页数：4
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