Roadmap on biosensing and photonics with advanced nano-optical methods

被引：57

作者：

Di Fabrizio, Enzo ^{[1
]}

Schluecker, Sebastian ^{[2
,3
]}

Wenger, Jerome ^{[4
]}

Regmi, Raju ^{[4
]}

Rigneault, Herve ^{[4
]}

Calafiore, Giuseppe ^{[5
]}

West, Melanie ^{[5
]}

Cabrini, Stefano ^{[5
]}

Fleischer, Monika ^{[6
,7
]}

van Hulst, Niek F. ^{[8
,9
]}

Garcia-Parajo, Maria F. ^{[8
,9
]}

Pucci, Annemarie ^{[10
]}

Cojoc, Dan ^{[11
]}

Hauser, Charlotte A. E. ^{[12
]}

Ni, Ming ^{[13
]}

机构：

[1] King Abdullah Univ Sci & Technol, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia

[2] Univ Duisburg Essen, Fac Chem, Phys Chem 1, Univ Str 5, D-45141 Essen, Germany

[3] Univ Duisburg Essen, Ctr Nanointegrat Duisburg Essen CENIDE, Univ Str 5, D-45141 Essen, Germany

[4] Aix Marseille Univ, CNRS, Cent Marseille, Inst Fresnel,UMR 7249, F-13013 Marseille, France

[5] Lawrence Berkeley Natl Lab, Mol Foundry, 1 Cyclotron Rd, Berkeley, CA 94702 USA

[6] Univ Tubingen, Inst Appl Phys, Morgenstelle 10, D-72076 Tubingen, Germany

[7] Univ Tubingen, Ctr LISA, Morgenstelle 10, D-72076 Tubingen, Germany

[8] Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Mediterranean Technol Pk, Castelldefels 08860, Barcelona, Spain

[9] ICREA, Barcelona 08010, Spain

[10] Heidelberg Univ, Kirchhoff Inst Phys, Neuenheimer Feld 227, D-69120 Heidelberg, Germany

[11] CNR, IOM Inst Mat, Area Sci Pk Basovizza,SS 14 Km 163-5, I-34149 Trieste, Italy

[12] King Abdullah Univ Sci & Technol, Lab Nanomed, Div Biol & Environm Sci & Engn, 4700 KAUST, Thuwal 239556900, Saudi Arabia

[13] ASTAR, Inst Bioengn & Nanotechnol, 31 Biopolis Way,Nanos 04-01, Singapore 138669, Singapore

来源：

JOURNAL OF OPTICS | 2016年 / 18卷 / 06期

关键词：

biophotonics; biosensing; nanomedicine; nanophotonics; plasmonics; SURFACE-PLASMON RESONANCE; SINGLE-MOLECULE ANALYSIS; LABEL-FREE DETECTION; MODE WAVE-GUIDES; LIVING CELL; SELF-ASSEMBLE; REAL-TIME; ANTENNAS; FLUORESCENCE; MICROSCOPY;

D O I：

10.1088/2040-8978/18/6/063003

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

This roadmap, through the contributions of ten groups worldwide, contains different techniques, methods and materials devoted to sensing in nanomedicine. Optics is used in different ways in the detection schemes. Raman, fluorescence and infrared spectroscopies, plasmonics, second harmonic generation and optical tweezers are all used in applications from single molecule detection (both in highly diluted and in highly concentrated solutions) to single cell manipulation. In general, each optical scheme, through device miniaturization and electromagnetic field localization, exploits an intrinsic optical enhancement mechanism in order to increase the sensitivity and selectivity of the device with respect to the complex molecular construct. The materials used for detection include nanoparticles and nanostructures fabricated with different 2D and 3D lithographic methods. It is shown that sensitivity to a single molecule is already accessible whether the system under study is a single cell or a multitude of cells in a molecular mixture. Throughout the roadmap there is an attempt to foresee and to suggest future directions in this interdisciplinary field.

引用

页数：27

共 99 条

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