The development of services provided by the National Library of Medicine (NLM), which dates back to 1836, is described. MEDLINE, a database of 10-plus million references and abstracts to the world's biomedical literature, was put on the World Wide Web for free searching in 1997 as a system called PubMed, whose use has grown to over 250 million searches per year. PubMed features a variety of links between MEDLINE references and related information - full-text journal articles, DNA sequence data, medical knowledge bases, etc. - at websites within and outside NLM. PubMed is a major component of a larger NLM system, Entrez, which integrates access to a number of genome-related databases with linking features similar to those of PubMed. The newest linked service, which became a reality in February 2000, is PubMed Central, the National Institutes of Health's free repository fbr primary research reports in all the life sciences.