RETRACTED: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours (Retracted Article)

被引：0

作者：

Boller, Danielle ^{[1
]}

Doepfner, Kathrin T. ^{[1
]}

De Laurentiis, Angela ^{[1
]}

Guerreiro, Ana S. ^{[1
]}

Marinov, Marin ^{[1
]}

Shalaby, Tarek ^{[3
]}

Depledge, Paul ^{[4
]}

Robson, Anthony ^{[4
]}

Saghir, Nahid ^{[4
]}

Hayakawa, Masahiko ^{[5
]}

Kaizawa, Hiroyuki ^{[5
]}

Koizumi, Tomonobu ^{[5
]}

Ohishi, Takahide ^{[5
]}

Fattet, Sarah ^{[6
]}

Delattre, Olivier ^{[6
]}

Schweri-Olac, Anelia

Hoeland, Katrin

Grotzer, Michael A. ^{[3
]}

Frei, Karl ^{[7
]}

Spertini, Olivier ^{[8
]}

Waterfield, Michael D. ^{[4
,9
]}

Arcaro, Alexandre ^{[1
,2
]}

机构：

[1] Univ Childrens Hosp Zurich, Div Clin Chem & Biochem, Zurich, Switzerland

[2] Univ Bern, Div Pediat Hematol Oncol, Dept Clin Res, CH-3004 Bern, Switzerland

[3] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland

[4] Plramed, Slough, Berks, England

[5] Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki, Japan

[6] INSERM, U509, Paris, France

[7] Univ Zurich Hosp, Dept Neurosurg, CH-8091 Zurich, Switzerland

[8] CHU Vaudois, Serv & Cent Lab Hematol, Lausanne, Switzerland

[9] Ludwig Inst Canc Res, Proteom Unit, London W1P 8BT, England

来源：

ANTICANCER RESEARCH | 2012年 / 32卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

PI3KC2; beta; pharmacological inhibition; cell proliferation; migration; acute leukemia; brain tumours; neuroendocrine tumours; II PHOSPHOINOSITIDE 3-KINASE; ACUTE MYELOID-LEUKEMIA; PI3-KINASE P110-ALPHA INHIBITORS; PHOSPHATIDYLINOSITOL; 3-KINASE; BIOLOGICAL EVALUATION; C2; DOMAIN; CELL-MIGRATION; HUMAN CANCER; NEUROBLASTOMA-CELLS; DEPENDENT MECHANISM;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into three classes. While class I isoforms have been well-studied in cancer, little is known about the functions of class II PI3Ks. Materials and Methods: The expression pattern and functions of the class II PI3KC2 beta isoform were investigated in a panel of tumour samples and cell lines. Results: Overexpression of PI3KC2 beta was found in subsets of tumours and cell lines from acute myeloid leukemia (AML), glioblastoma multiforme (GBM), medulloblastoma (MB), neuroblastoma (NB), and small cell lung cancer (SCLC). Specific pharmacological inhibitors of PI3KC2 beta or RNA interference impaired proliferation of a panel of human cancer cell lines and primary cultures. Inhibition of PI3KC2 beta also induced apoptosis and sensitised the cancer cells to chemotherapeutic agents. Conclusion: Together, these data show that PI3KC2 beta contributes to proliferation and survival in AML, brain tumours and neuroendocrine tumours, and may represent a novel target in these malignancies.

引用

页码：3015 / 3027

页数：13

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